Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia

Presynaptic increase in striatal dopamine is the primary dopaminergic abnormality in schizophrenia, but the underlying mechanisms are not understood. Here, we hypothesized that increased expression of endogenous GDNF could induce dopaminergic abnormalities that resemble those seen in schizophrenia....

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Detalles Bibliográficos
Autores principales: Mätlik, Kärt, Garton, Daniel R., Montaño-Rodríguez, Ana R., Olfat, Soophie, Eren, Feride, Casserly, Laoise, Damdimopoulos, Anastasios, Panhelainen, Anne, Porokuokka, L. Lauriina, Kopra, Jaakko J., Turconi, Giorgio, Schweizer, Nadine, Bereczki, Erika, Piehl, Fredrik, Engberg, Göran, Cervenka, Simon, Piepponen, T. Petteri, Zhang, Fu-Ping, Sipilä, Petra, Jakobsson, Johan, Sellgren, Carl M., Erhardt, Sophie, Andressoo, Jaan-Olle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708553/
https://www.ncbi.nlm.nih.gov/pubmed/35618883
http://dx.doi.org/10.1038/s41380-022-01554-2

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