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Brain integrity is altered by hepatic APOE ε4 in humanized-liver mice

Liver-generated plasma apolipoprotein E (apoE) does not enter the brain but nonetheless correlates with Alzheimer’s disease (AD) risk and AD biomarker levels. Carriers of APOEε4, the strongest genetic AD risk factor, exhibit lower plasma apoE and altered brain integrity already at mid-life versus no...

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Detalles Bibliográficos
Autores principales:	Giannisis, Andreas, Patra, Kalicharan, Edlund, Anna K., Nieto, Lur Agirrezabala, Benedicto-Gras, Joan, Moussaud, Simon, de la Rosa, Andrés, Twohig, Daniel, Bengtsson, Tore, Fu, Yuan, Bu, Guojun, Bial, Greg, Foquet, Lander, Hammarstedt, Christina, Strom, Stephen, Kannisto, Kristina, Raber, Jacob, Ellis, Ewa, Nielsen, Henrietta M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708568/ https://www.ncbi.nlm.nih.gov/pubmed/35418601 http://dx.doi.org/10.1038/s41380-022-01548-0

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