Alcohol use disorder is associated with DNA methylation-based shortening of telomere length and regulated by TESPA1: implications for aging

Chronic heavy alcohol consumption is associated with increased mortality and morbidity and often leads to premature aging; however, the mechanisms of alcohol-associated cellular aging are not well understood. In this study, we used DNA methylation derived telomere length (DNAmTL) as a novel approach...

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Detalles Bibliográficos
Autores principales: Jung, Jeesun, McCartney, Daniel L., Wagner, Josephin, Rosoff, Daniel B., Schwandt, Melanie, Sun, Hui, Wiers, Corinde E., de Carvalho, Luana Martins, Volkow, Nora D., Walker, Rosie M., Campbell, Archie, Porteous, David J., McIntosh, Andrew M., Marioni, Riccardo E., Horvath, Steve, Evans, Kathryn L., Lohoff, Falk W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708583/
https://www.ncbi.nlm.nih.gov/pubmed/35705636
http://dx.doi.org/10.1038/s41380-022-01624-5

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