Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning

Acetylcholine is a neuromodulator critical for learning and memory. The cholinesterase inhibitor donepezil increases brain acetylcholine levels and improves Alzheimer’s disease (AD)-associated learning disabilities. Acetylcholine activates striatal/nucleus accumbens dopamine receptor D2-expressing m...

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Detalles Bibliográficos
Autores principales: Yamahashi, Yukie, Lin, You-Hsin, Mouri, Akihiro, Iwanaga, Sho, Kawashima, Kazuhiro, Tokumoto, Yuya, Watanabe, Yo, Faruk, Md. Omar, Zhang, Xinjian, Tsuboi, Daisuke, Nakano, Takashi, Saito, Naoaki, Nagai, Taku, Yamada, Kiyofumi, Kaibuchi, Kozo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708603/
https://www.ncbi.nlm.nih.gov/pubmed/35665767
http://dx.doi.org/10.1038/s41380-022-01643-2

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