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Risk factors for pulmonary infection in elderly patients with acute stroke: A meta-analysis

OBJECTIVE: The study aims to systematically evaluate the risk factors of pulmonary infection in elderly patients with acute stroke. METHODS: PubMed, CENTRAL, CINAHL, Web of Science, Embase, and four Chinese databases (CNKI, SinoMed, VIP, and Wanfang databases) for studies involving risk factors of p...

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Autores principales: You, Qian, Bai, Dingxi, Wu, Chenxi, Wang, Hao, Chen, Xinyu, Gao, Jing, Hou, Chaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708625/
https://www.ncbi.nlm.nih.gov/pubmed/36468115
http://dx.doi.org/10.1016/j.heliyon.2022.e11664
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author You, Qian
Bai, Dingxi
Wu, Chenxi
Wang, Hao
Chen, Xinyu
Gao, Jing
Hou, Chaoming
author_facet You, Qian
Bai, Dingxi
Wu, Chenxi
Wang, Hao
Chen, Xinyu
Gao, Jing
Hou, Chaoming
author_sort You, Qian
collection PubMed
description OBJECTIVE: The study aims to systematically evaluate the risk factors of pulmonary infection in elderly patients with acute stroke. METHODS: PubMed, CENTRAL, CINAHL, Web of Science, Embase, and four Chinese databases (CNKI, SinoMed, VIP, and Wanfang databases) for studies involving risk factors of pulmonary infection in elderly patients with acute stroke were searched. Then, two researchers independently read the article titles and abstracts to screen the literature, extracted relevant research data, and evaluated the methodological quality. Finally, a meta-analysis was performed. RESULTS: In total, fifteen studies were included, with medium and high-grade quality. Meta-analysis results showed: age [OR = 1.70, 95% CI (1.27, 2.29), P = 0.0004], type of stroke [OR = 1.30, 95% CI (1.21, 1.40), P < 0.00001], conscious disturbance [OR = 2.27, 95% CI (1.44, 3.58), P = 0.0004], dysphagia [OR = 3.24, 95% CI (2.06, 5.12), P < 0.00001], diabetes mellitus [OR = 2.35, 95% CI (1.23, 4.48), P = 0.010], hypertension [OR = 2.05, 95% CI (1.83, 2.31), P < 0.0001], chronic obstructive pulmonary disease (COPD) [OR = 2.69, 95% CI (1.90, 3.81), P < 0.00001], hyperlipidemia [OR = 1.29, 95% CI (1.19, 1.39), P < 0.00001], invasive procedure [OR = 3.37, 95% CI (2.30, 4.94), P < 0.00001], hospital stays [OR = 1.41, 95% CI (1.22, 1.62), P < 0.00001], bedridden time [OR = 1.51, 95% CI (1.36, 1.68), P < 0.00001], and National Institute of Health Stroke Scale (NIHSS) score [OR = 1.67, 95% CI (1.02, 2.75), P = 0.04] were independent risk factors. Glasgow Coma Scale (GCS) score was not a risk factor. However, the relationship between atrial fibrillation, smoking history, and pulmonary infection in elderly patients with acute stroke needs further proof. CONCLUSIONS: Age, type of stroke, conscious disturbance, dysphagia, diabetes mellitus, hypertension, COPD, hyperlipidemia, invasive procedure, hospital stays, bedridden time, and NIHSS score were risk factors for pulmonary infection in elderly patients with acute stroke.
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spelling pubmed-97086252022-12-01 Risk factors for pulmonary infection in elderly patients with acute stroke: A meta-analysis You, Qian Bai, Dingxi Wu, Chenxi Wang, Hao Chen, Xinyu Gao, Jing Hou, Chaoming Heliyon Review Article OBJECTIVE: The study aims to systematically evaluate the risk factors of pulmonary infection in elderly patients with acute stroke. METHODS: PubMed, CENTRAL, CINAHL, Web of Science, Embase, and four Chinese databases (CNKI, SinoMed, VIP, and Wanfang databases) for studies involving risk factors of pulmonary infection in elderly patients with acute stroke were searched. Then, two researchers independently read the article titles and abstracts to screen the literature, extracted relevant research data, and evaluated the methodological quality. Finally, a meta-analysis was performed. RESULTS: In total, fifteen studies were included, with medium and high-grade quality. Meta-analysis results showed: age [OR = 1.70, 95% CI (1.27, 2.29), P = 0.0004], type of stroke [OR = 1.30, 95% CI (1.21, 1.40), P < 0.00001], conscious disturbance [OR = 2.27, 95% CI (1.44, 3.58), P = 0.0004], dysphagia [OR = 3.24, 95% CI (2.06, 5.12), P < 0.00001], diabetes mellitus [OR = 2.35, 95% CI (1.23, 4.48), P = 0.010], hypertension [OR = 2.05, 95% CI (1.83, 2.31), P < 0.0001], chronic obstructive pulmonary disease (COPD) [OR = 2.69, 95% CI (1.90, 3.81), P < 0.00001], hyperlipidemia [OR = 1.29, 95% CI (1.19, 1.39), P < 0.00001], invasive procedure [OR = 3.37, 95% CI (2.30, 4.94), P < 0.00001], hospital stays [OR = 1.41, 95% CI (1.22, 1.62), P < 0.00001], bedridden time [OR = 1.51, 95% CI (1.36, 1.68), P < 0.00001], and National Institute of Health Stroke Scale (NIHSS) score [OR = 1.67, 95% CI (1.02, 2.75), P = 0.04] were independent risk factors. Glasgow Coma Scale (GCS) score was not a risk factor. However, the relationship between atrial fibrillation, smoking history, and pulmonary infection in elderly patients with acute stroke needs further proof. CONCLUSIONS: Age, type of stroke, conscious disturbance, dysphagia, diabetes mellitus, hypertension, COPD, hyperlipidemia, invasive procedure, hospital stays, bedridden time, and NIHSS score were risk factors for pulmonary infection in elderly patients with acute stroke. Elsevier 2022-11-24 /pmc/articles/PMC9708625/ /pubmed/36468115 http://dx.doi.org/10.1016/j.heliyon.2022.e11664 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
You, Qian
Bai, Dingxi
Wu, Chenxi
Wang, Hao
Chen, Xinyu
Gao, Jing
Hou, Chaoming
Risk factors for pulmonary infection in elderly patients with acute stroke: A meta-analysis
title Risk factors for pulmonary infection in elderly patients with acute stroke: A meta-analysis
title_full Risk factors for pulmonary infection in elderly patients with acute stroke: A meta-analysis
title_fullStr Risk factors for pulmonary infection in elderly patients with acute stroke: A meta-analysis
title_full_unstemmed Risk factors for pulmonary infection in elderly patients with acute stroke: A meta-analysis
title_short Risk factors for pulmonary infection in elderly patients with acute stroke: A meta-analysis
title_sort risk factors for pulmonary infection in elderly patients with acute stroke: a meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708625/
https://www.ncbi.nlm.nih.gov/pubmed/36468115
http://dx.doi.org/10.1016/j.heliyon.2022.e11664
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