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Randomized placebo-controlled trial of oral tannin supplementation on COVID-19 symptoms, gut dysbiosis and cytokine response

The clinical study aim was to investigate whether a tannin-based dietary supplementation could improve the efficacy of standard-of-care treatment of hospitalized COVID-19 patients by restoring gut microbiota function. Adverse events and immunomodulation post-tannin supplementation were also investig...

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Autores principales: Molino, Silvia, Pisarevsky, Andrea, Badu, Shyam, Wu, Qinglong, Mingorance, Fabiana López, Vega, Patricia, Stefanolo, Juan Pablo, Repetti, Julieta, Ludueña, Guillermina, Pepa, Pablo, Olmos, Juan Ignacio, Fermepin, Marcelo Rodriguez, Uehara, Tatiana, Viciani, Elisa, Castagnetti, Andrea, Savidge, Tor, Piskorz, María Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708634/
https://www.ncbi.nlm.nih.gov/pubmed/36467850
http://dx.doi.org/10.1016/j.jff.2022.105356
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author Molino, Silvia
Pisarevsky, Andrea
Badu, Shyam
Wu, Qinglong
Mingorance, Fabiana López
Vega, Patricia
Stefanolo, Juan Pablo
Repetti, Julieta
Ludueña, Guillermina
Pepa, Pablo
Olmos, Juan Ignacio
Fermepin, Marcelo Rodriguez
Uehara, Tatiana
Viciani, Elisa
Castagnetti, Andrea
Savidge, Tor
Piskorz, María Marta
author_facet Molino, Silvia
Pisarevsky, Andrea
Badu, Shyam
Wu, Qinglong
Mingorance, Fabiana López
Vega, Patricia
Stefanolo, Juan Pablo
Repetti, Julieta
Ludueña, Guillermina
Pepa, Pablo
Olmos, Juan Ignacio
Fermepin, Marcelo Rodriguez
Uehara, Tatiana
Viciani, Elisa
Castagnetti, Andrea
Savidge, Tor
Piskorz, María Marta
author_sort Molino, Silvia
collection PubMed
description The clinical study aim was to investigate whether a tannin-based dietary supplementation could improve the efficacy of standard-of-care treatment of hospitalized COVID-19 patients by restoring gut microbiota function. Adverse events and immunomodulation post-tannin supplementation were also investigated. A total of 124 patients receiving standard-of-care treatment were randomized to oral tannin-based supplement or placebo for a total of 14 days. Longitudinal blood and stool samples were collected for cytokine and 16S rDNA microbiome profiling, and results were compared with 53 healthy controls. Although oral tannin supplementation did not result in clinical improvement or significant gut microbiome shifts after 14-days, a reduction in the inflammatory state was evident and significantly correlated with microbiota modulation. Among cytokines measured, MIP-1α was significantly decreased with tannin treatment (p = 0.03) where it correlated positively with IL-1β and TNF- α, and negatively with stool Bifidobacterium abundance.
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spelling pubmed-97086342022-11-30 Randomized placebo-controlled trial of oral tannin supplementation on COVID-19 symptoms, gut dysbiosis and cytokine response Molino, Silvia Pisarevsky, Andrea Badu, Shyam Wu, Qinglong Mingorance, Fabiana López Vega, Patricia Stefanolo, Juan Pablo Repetti, Julieta Ludueña, Guillermina Pepa, Pablo Olmos, Juan Ignacio Fermepin, Marcelo Rodriguez Uehara, Tatiana Viciani, Elisa Castagnetti, Andrea Savidge, Tor Piskorz, María Marta J Funct Foods Article The clinical study aim was to investigate whether a tannin-based dietary supplementation could improve the efficacy of standard-of-care treatment of hospitalized COVID-19 patients by restoring gut microbiota function. Adverse events and immunomodulation post-tannin supplementation were also investigated. A total of 124 patients receiving standard-of-care treatment were randomized to oral tannin-based supplement or placebo for a total of 14 days. Longitudinal blood and stool samples were collected for cytokine and 16S rDNA microbiome profiling, and results were compared with 53 healthy controls. Although oral tannin supplementation did not result in clinical improvement or significant gut microbiome shifts after 14-days, a reduction in the inflammatory state was evident and significantly correlated with microbiota modulation. Among cytokines measured, MIP-1α was significantly decreased with tannin treatment (p = 0.03) where it correlated positively with IL-1β and TNF- α, and negatively with stool Bifidobacterium abundance. The Authors. Published by Elsevier Ltd. 2022-12 2022-11-30 /pmc/articles/PMC9708634/ /pubmed/36467850 http://dx.doi.org/10.1016/j.jff.2022.105356 Text en © 2022 The Authors. Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Molino, Silvia
Pisarevsky, Andrea
Badu, Shyam
Wu, Qinglong
Mingorance, Fabiana López
Vega, Patricia
Stefanolo, Juan Pablo
Repetti, Julieta
Ludueña, Guillermina
Pepa, Pablo
Olmos, Juan Ignacio
Fermepin, Marcelo Rodriguez
Uehara, Tatiana
Viciani, Elisa
Castagnetti, Andrea
Savidge, Tor
Piskorz, María Marta
Randomized placebo-controlled trial of oral tannin supplementation on COVID-19 symptoms, gut dysbiosis and cytokine response
title Randomized placebo-controlled trial of oral tannin supplementation on COVID-19 symptoms, gut dysbiosis and cytokine response
title_full Randomized placebo-controlled trial of oral tannin supplementation on COVID-19 symptoms, gut dysbiosis and cytokine response
title_fullStr Randomized placebo-controlled trial of oral tannin supplementation on COVID-19 symptoms, gut dysbiosis and cytokine response
title_full_unstemmed Randomized placebo-controlled trial of oral tannin supplementation on COVID-19 symptoms, gut dysbiosis and cytokine response
title_short Randomized placebo-controlled trial of oral tannin supplementation on COVID-19 symptoms, gut dysbiosis and cytokine response
title_sort randomized placebo-controlled trial of oral tannin supplementation on covid-19 symptoms, gut dysbiosis and cytokine response
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708634/
https://www.ncbi.nlm.nih.gov/pubmed/36467850
http://dx.doi.org/10.1016/j.jff.2022.105356
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