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Neural substrates underlying effortful control deficit in autism spectrum disorder: a meta-analysis of fMRI studies

Effortful control comprises attentional control, inhibitory control, and cognitive flexibility subprocesses. Effortful control is impaired in individuals with autism spectrum disorder, yet its neural underpinnings remain elusive. By conducting a coordinate-based meta-analysis, this study compared th...

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Autores principales: Krishnamurthy, Karthikeyan, Chan, Melody M. Y., Han, Yvonne M. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708641/
https://www.ncbi.nlm.nih.gov/pubmed/36446840
http://dx.doi.org/10.1038/s41598-022-25051-2
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author Krishnamurthy, Karthikeyan
Chan, Melody M. Y.
Han, Yvonne M. Y.
author_facet Krishnamurthy, Karthikeyan
Chan, Melody M. Y.
Han, Yvonne M. Y.
author_sort Krishnamurthy, Karthikeyan
collection PubMed
description Effortful control comprises attentional control, inhibitory control, and cognitive flexibility subprocesses. Effortful control is impaired in individuals with autism spectrum disorder, yet its neural underpinnings remain elusive. By conducting a coordinate-based meta-analysis, this study compared the brain activation patterns between autism and typically developing individuals and examined the effect of age on brain activation in each effortful control subprocesses. Meta-analytic results from 22 studies revealed that, individuals with autism showed hypoactivation in the default mode network for tasks tapping inhibitory control functioning (threshold-free cluster enhancement p < 0.001). When these individuals perform tasks tapping attentional control and cognitive flexibility, they exhibited aberrant activation in various brain networks including default mode network, dorsal attention, frontoparietal, visual and somatomotor networks (uncorrected ps < 0.005). Meta-regression analyses revealed that brain regions within the default mode network showed a significant decreasing trend in activation with increasing age (uncorrected p < 0.05). In summary, individuals with autism showed aberrant activation patterns across multiple brain functional networks during all cognitive tasks supporting effortful control, with some regions showing a decrease in activation with increasing age.
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spelling pubmed-97086412022-12-01 Neural substrates underlying effortful control deficit in autism spectrum disorder: a meta-analysis of fMRI studies Krishnamurthy, Karthikeyan Chan, Melody M. Y. Han, Yvonne M. Y. Sci Rep Article Effortful control comprises attentional control, inhibitory control, and cognitive flexibility subprocesses. Effortful control is impaired in individuals with autism spectrum disorder, yet its neural underpinnings remain elusive. By conducting a coordinate-based meta-analysis, this study compared the brain activation patterns between autism and typically developing individuals and examined the effect of age on brain activation in each effortful control subprocesses. Meta-analytic results from 22 studies revealed that, individuals with autism showed hypoactivation in the default mode network for tasks tapping inhibitory control functioning (threshold-free cluster enhancement p < 0.001). When these individuals perform tasks tapping attentional control and cognitive flexibility, they exhibited aberrant activation in various brain networks including default mode network, dorsal attention, frontoparietal, visual and somatomotor networks (uncorrected ps < 0.005). Meta-regression analyses revealed that brain regions within the default mode network showed a significant decreasing trend in activation with increasing age (uncorrected p < 0.05). In summary, individuals with autism showed aberrant activation patterns across multiple brain functional networks during all cognitive tasks supporting effortful control, with some regions showing a decrease in activation with increasing age. Nature Publishing Group UK 2022-11-29 /pmc/articles/PMC9708641/ /pubmed/36446840 http://dx.doi.org/10.1038/s41598-022-25051-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Krishnamurthy, Karthikeyan
Chan, Melody M. Y.
Han, Yvonne M. Y.
Neural substrates underlying effortful control deficit in autism spectrum disorder: a meta-analysis of fMRI studies
title Neural substrates underlying effortful control deficit in autism spectrum disorder: a meta-analysis of fMRI studies
title_full Neural substrates underlying effortful control deficit in autism spectrum disorder: a meta-analysis of fMRI studies
title_fullStr Neural substrates underlying effortful control deficit in autism spectrum disorder: a meta-analysis of fMRI studies
title_full_unstemmed Neural substrates underlying effortful control deficit in autism spectrum disorder: a meta-analysis of fMRI studies
title_short Neural substrates underlying effortful control deficit in autism spectrum disorder: a meta-analysis of fMRI studies
title_sort neural substrates underlying effortful control deficit in autism spectrum disorder: a meta-analysis of fmri studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708641/
https://www.ncbi.nlm.nih.gov/pubmed/36446840
http://dx.doi.org/10.1038/s41598-022-25051-2
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