Fasting increases susceptibility to acute myocardial ischaemia/reperfusion injury through a sirtuin-3 mediated increase in fatty acid oxidation

Fasting increases susceptibility to acute myocardial ischaemia/reperfusion injury (IRI) but the mechanisms are unknown. Here, we investigate the role of the mitochondrial NAD(+)-dependent deacetylase, Sirtuin-3 (SIRT3), which has been shown to influence fatty acid oxidation and cardiac outcomes, as...

Descripción completa

Detalles Bibliográficos
Autores principales: Hall, Andrew R., Karwi, Qutuba G., Kumar, Sanjeev, Dongworth, Rachel, Aksentijević, Dunja, Altamimi, Tariq R., Fridianto, Kevin Timothy, Chinda, Kroekkiat, Hernandez-Resendiz, Sauri, Mahmood, Mohammad U., Michelakis, Evangelos, Ramachandra, Chrishan J., Ching, Jianhong, Vicencio, Jose M., Shattock, Michael J., Kovalik, Jean-Paul, Yellon, Derek M., Lopaschuk, Gary, Hausenloy, Derek J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708654/
https://www.ncbi.nlm.nih.gov/pubmed/36446868
http://dx.doi.org/10.1038/s41598-022-23847-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708654/
https://www.ncbi.nlm.nih.gov/pubmed/36446868
http://dx.doi.org/10.1038/s41598-022-23847-w

Ejemplares similares