Structures of the R-type human Ca(v)2.3 channel reveal conformational crosstalk of the intracellular segments

The R-type voltage-gated Ca(2+) (Ca(v)) channels Ca(v)2.3, widely expressed in neuronal and neuroendocrine cells, represent potential drug targets for pain, seizures, epilepsy, and Parkinson’s disease. Despite their physiological importance, there have lacked selective small-molecule inhibitors targ...

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Detalles Bibliográficos
Autores principales: Yao, Xia, Wang, Yan, Wang, Zhifei, Fan, Xiao, Wu, Di, Huang, Jian, Mueller, Alexander, Gao, Sarah, Hu, Miaohui, Robinson, Carol V., Yu, Yong, Gao, Shuai, Yan, Nieng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708679/
https://www.ncbi.nlm.nih.gov/pubmed/36446785
http://dx.doi.org/10.1038/s41467-022-35026-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708679/
https://www.ncbi.nlm.nih.gov/pubmed/36446785
http://dx.doi.org/10.1038/s41467-022-35026-6

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