Cargando…

Structures of the R-type human Ca(v)2.3 channel reveal conformational crosstalk of the intracellular segments

The R-type voltage-gated Ca(2+) (Ca(v)) channels Ca(v)2.3, widely expressed in neuronal and neuroendocrine cells, represent potential drug targets for pain, seizures, epilepsy, and Parkinson’s disease. Despite their physiological importance, there have lacked selective small-molecule inhibitors targ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yao, Xia, Wang, Yan, Wang, Zhifei, Fan, Xiao, Wu, Di, Huang, Jian, Mueller, Alexander, Gao, Sarah, Hu, Miaohui, Robinson, Carol V., Yu, Yong, Gao, Shuai, Yan, Nieng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708679/ https://www.ncbi.nlm.nih.gov/pubmed/36446785 http://dx.doi.org/10.1038/s41467-022-35026-6

Ejemplares similares

Structural Basis of the Modulation of the Voltage‐Gated Calcium Ion Channel Ca(v)1.1 by Dihydropyridine Compounds
por: Gao, Shuai, et al.
Publicado: (2020)

Structural basis for pore blockade of human voltage-gated calcium channel Ca(v)1.3 by motion sickness drug cinnarizine
por: Yao, Xia, et al.
Publicado: (2022)

Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm
por: Qian, Hongwu, et al.
Publicado: (2019)

Intracellular zinc protects Kv7 K(+) channels from Ca(2+)/calmodulin-mediated inhibition
por: Yang, Xinhe, et al.
Publicado: (2022)

Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca(V)2.3
por: Gao, Yiwei, et al.
Publicado: (2023)

An Intracellular Ca(2+) Channel is Required For Sarcolemma Repair to Prevent Muscular Dystrophy
por: Cheng, Xiping, et al.
Publicado: (2014)

SR-Mitochondria Crosstalk Shapes Ca Signalling to Impact Pathophenotype in Disease Models Marked by Dysregulated Intracellular Ca Release( )
por: Tow, Brian D, et al.
Publicado: (2021)

Crosstalk and the evolvability of intracellular communication
por: Rowland, Michael A., et al.
Publicado: (2017)

Comparative characterization of two intracellular Ca(2+)-release channels from the red flour beetle, Tribolium castaneum
por: Liu, Yaping, et al.
Publicado: (2014)

And Yet It Moves: Conformational States of the Ca(2+) Channel Pore
por: Olcese, Riccardo
Publicado: (2007)

Modulation of the Voltage Sensor of L-type Ca(2+) Channels by Intracellular Ca(2+)
por: Isaev, Dmytro, et al.
Publicado: (2004)

Comparative Ca(2+) channel contributions to intracellular Ca(2+) levels in the circadian clock
por: Plante, Amber E., et al.
Publicado: (2021)

TRPC channels blockade abolishes endotoxemic cardiac dysfunction by hampering intracellular inflammation and Ca(2+) leakage
por: Tang, Na, et al.
Publicado: (2022)

Structure-based assessment of disease-related mutations in human voltage-gated sodium channels
por: Huang, Weiyun, et al.
Publicado: (2017)

Cryo-EM structure of human voltage-gated sodium channel Na(v)1.6
por: Fan, Xiao, et al.
Publicado: (2023)

Apamin Boosting of Synaptic Potentials in Ca(V)2.3 R-Type Ca(2+) Channel Null Mice
por: Wang, Kang, et al.
Publicado: (2015)

Dynamin- and Rab5-Dependent Endocytosis of a Ca(2+)-Activated K(+) Channel, KCa2.3
por: Gao, Yajuan, et al.
Publicado: (2012)

Optimal microdomain crosstalk between endoplasmic reticulum and mitochondria for Ca(2+) oscillations
por: Qi, Hong, et al.
Publicado: (2015)

The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening
por: Bai, Xiao-Chen, et al.
Publicado: (2016)

Signaling between intracellular Ca2+ stores and depletion-activated Ca2+ channels generates [Ca2+]i oscillations in T lymphocytes
Publicado: (1994)

Intracellular pH modulates the availability of vascular L-type Ca2+ channels
Publicado: (1994)

Vascular Kv7 channels control intracellular Ca(2+) dynamics in smooth muscle
por: Tsai, Yuan-Ming, et al.
Publicado: (2020)

A Transcriptional Reporter of Intracellular Ca(2+) in Drosophila
por: Gao, Xiaojing J, et al.
Publicado: (2015)

Crosstalk Defect Detection Method Based on Salient Color Channel Frequency Domain Filtering
por: Xie, Wenqiang, et al.
Publicado: (2022)

Pharmacological Dissection of the Crosstalk between Na(V) and Ca(V) Channels in GH3b6 Cells
por: Réthoré, Léa, et al.
Publicado: (2022)

Intracellular Ca(2+) Inhibits Smooth Muscle L-Type Ca(2+) Channels by Activation of Protein Phosphatase Type 2B and by Direct Interaction with the Channel
por: Schuhmann, Klaus, et al.
Publicado: (1997)

Down-regulation of K(Ca)2.3 channels causes erectile dysfunction in mice
por: Comerma-Steffensen, Simon, et al.
Publicado: (2017)

How “Pharmacoresistant” is Ca(v)2.3, the Major Component of Voltage-Gated R-type Ca(2+) Channels?
por: Schneider, Toni, et al.
Publicado: (2013)

Arrhythmogenesis Toxicity of Aconitine Is Related to Intracellular Ca(2+) Signals
por: Zhou, Yu-hong, et al.
Publicado: (2013)

Probing the Cavity of the Slow Inactivated Conformation of Shaker Potassium Channels
por: Panyi, Gyorgy, et al.
Publicado: (2007)

Intracellular Mg(2+) Enhances the Function of Bk-Type Ca(2+)-Activated K(+) Channels
por: Shi, Jingyi, et al.
Publicado: (2001)

Identification and Functional Distribution of Intracellular Ca(2+) Channels in Mouse Lacrimal Gland Acinar Cells
por: Medina-Ortiz, W.E, et al.
Publicado: (2007)

Ca(2+)-activated K(+) Channels in Murine Endothelial Cells: Block by Intracellular Calcium and Magnesium
por: Ledoux, Jonathan, et al.
Publicado: (2008)

Menthol increases human glioblastoma intracellular Ca(2+), BK channel activity and cell migration
por: Wondergem, Robert, et al.
Publicado: (2009)

Ryanodine‐sensitive intracellular Ca(2+) channels are involved in the output from the SCN circadian clock
por: Aguilar‐Roblero, Raúl, et al.
Publicado: (2016)

Contribution of TRPC Channels to Intracellular Ca(2 +) Dyshomeostasis in Smooth Muscle From mdx Mice
por: Lopez, Jose R., et al.
Publicado: (2020)

GDF-15 enhances intracellular Ca(2+) by increasing Ca(v)1.3 expression in rat cerebellar granule neurons
por: Lu, Jun-Mei, et al.
Publicado: (2016)

Inhibition of intracellular proton-sensitive Ca(2+)-permeable TRPV3 channels protects against ischemic brain injury
por: Chen, Xiaoling, et al.
Publicado: (2022)

Neuroimmune Crosstalk in Rheumatoid Arthritis
por: Gao, Dashuang, et al.
Publicado: (2022)

Inhibition of K(Ca)2.2 and K(Ca)2.3 channel currents by protonation of outer pore histidine residues
por: Goodchild, Samuel J., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_v7bcc2tk81vjt8gal67sd5kn4p