Inhibition of the LRRC8A channel promotes microglia/macrophage phagocytosis and improves outcomes after intracerebral hemorrhagic stroke

Promoting microglial/macrophage (M/Mφ) phagocytosis accelerates hematoma clearance and improves the prognosis of intracerebral hemorrhagic stroke (ICH). Cation channels such as Piezo1 modulate bacterial clearance by regulating M/Mφ. Whether LRRC8A, an anion channel, affects M/Mφ erythrophagocytosis...

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Detalles Bibliográficos
Autores principales: Liu, Jing, Shen, Danmin, Wei, Chao, Wu, Weihua, Luo, Zhaoli, Hu, Liye, Xiao, Zhongnan, Hu, Tingting, Sun, Qingyu, Wang, Xiaotong, Ding, Yumeng, Liu, Meng, Pang, Miaoyi, Gai, Kaiyuan, Ma, Yiran, Tian, Yichen, Yu, Yan, Wang, Peipei, Guan, Yun, Xu, Meng, Yang, Fei, Li, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708789/
https://www.ncbi.nlm.nih.gov/pubmed/36465125
http://dx.doi.org/10.1016/j.isci.2022.105527

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