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Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period
We measured free and proteinic concentrations of native and modified amino acids from post-translational modifications (PTMs) and correlated them with the activity of SIRT1 and SIRT3 in the pellet and aqueous phases of human breast milk samples of ten lactating women during the neonatal period. SIRT...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708795/ https://www.ncbi.nlm.nih.gov/pubmed/35976439 http://dx.doi.org/10.1007/s00726-022-03197-7 |
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author | Baskal, Svetlana Beckmann, Bibiana Stahmer, Laura Peter, Corinna Bohnhorst, Bettina Das, Anibh Martin Tsikas, Dimitrios |
author_facet | Baskal, Svetlana Beckmann, Bibiana Stahmer, Laura Peter, Corinna Bohnhorst, Bettina Das, Anibh Martin Tsikas, Dimitrios |
author_sort | Baskal, Svetlana |
collection | PubMed |
description | We measured free and proteinic concentrations of native and modified amino acids from post-translational modifications (PTMs) and correlated them with the activity of SIRT1 and SIRT3 in the pellet and aqueous phases of human breast milk samples of ten lactating women during the neonatal period. SIRT1 and SIRT3 correlated directly with citrullination, asymmetric dimethylation and glycation of L-arginine, hydroxylation and glycation of L-lysine. SIRT1 and SIRT3 correlated inversely with the hydroxylation of L-proline. SIRT1 and SITR3 tended to correlate inversely with oxidative stress measured as malondialdehyde. Our study suggests that SIRT1 and SIRT3 may modulate PTMs in human breast milk cells. |
format | Online Article Text |
id | pubmed-9708795 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-97087952022-12-01 Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period Baskal, Svetlana Beckmann, Bibiana Stahmer, Laura Peter, Corinna Bohnhorst, Bettina Das, Anibh Martin Tsikas, Dimitrios Amino Acids Short Communication We measured free and proteinic concentrations of native and modified amino acids from post-translational modifications (PTMs) and correlated them with the activity of SIRT1 and SIRT3 in the pellet and aqueous phases of human breast milk samples of ten lactating women during the neonatal period. SIRT1 and SIRT3 correlated directly with citrullination, asymmetric dimethylation and glycation of L-arginine, hydroxylation and glycation of L-lysine. SIRT1 and SIRT3 correlated inversely with the hydroxylation of L-proline. SIRT1 and SITR3 tended to correlate inversely with oxidative stress measured as malondialdehyde. Our study suggests that SIRT1 and SIRT3 may modulate PTMs in human breast milk cells. Springer Vienna 2022-08-17 2022 /pmc/articles/PMC9708795/ /pubmed/35976439 http://dx.doi.org/10.1007/s00726-022-03197-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Short Communication Baskal, Svetlana Beckmann, Bibiana Stahmer, Laura Peter, Corinna Bohnhorst, Bettina Das, Anibh Martin Tsikas, Dimitrios Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period |
title | Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period |
title_full | Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period |
title_fullStr | Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period |
title_full_unstemmed | Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period |
title_short | Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period |
title_sort | possible role of sirt1 and sirt3 in post-translational modifications in human breast milk during the neonatal period |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708795/ https://www.ncbi.nlm.nih.gov/pubmed/35976439 http://dx.doi.org/10.1007/s00726-022-03197-7 |
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