Mechanism of KIT gene regulation by GATA1 lacking the N-terminal domain in Down syndrome–related myeloid disorders

Children with Down syndrome (DS) are at high risk of transient abnormal myelopoiesis (TAM) and myeloid leukemia of DS (ML-DS). GATA1 mutations are detected in almost all TAM and ML-DS samples, with exclusive expression of short GATA1 protein (GATA1s) lacking the N-terminal domain (NTD). However, it...

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Detalles Bibliográficos
Autores principales: Kanezaki, Rika, Toki, Tsutomu, Terui, Kiminori, Sato, Tomohiko, Kobayashi, Akie, Kudo, Ko, Kamio, Takuya, Sasaki, Shinya, Kawaguchi, Koji, Watanabe, Kenichiro, Ito, Etsuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708825/
https://www.ncbi.nlm.nih.gov/pubmed/36447001
http://dx.doi.org/10.1038/s41598-022-25046-z

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