Engineering receptors in the secretory pathway for orthogonal signalling control

Synthetic receptors targeted to the secretory pathway often fail to exhibit the expected activity due to post-translational modifications (PTMs) and/or improper folding. Here, we engineered synthetic receptors that reside in the cytoplasm, inside the endoplasmic reticulum (ER), or on the plasma memb...

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Detalles Bibliográficos
Autores principales: Mahameed, Mohamed, Wang, Pengli, Xue, Shuai, Fussenegger, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708828/
https://www.ncbi.nlm.nih.gov/pubmed/36446786
http://dx.doi.org/10.1038/s41467-022-35161-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708828/
https://www.ncbi.nlm.nih.gov/pubmed/36446786
http://dx.doi.org/10.1038/s41467-022-35161-0

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