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Exploring the causality between ankylosing spondylitis and atrial fibrillation: A two-sample Mendelian randomization study

Objective: To study whether ankylosing spondylitis (AS) has a causal effect on the risk of atrial fibrillation (AF) using two-sample Mendelian randomization (MR) analysis. Methods: Single nucleotide polymorphisms (SNPs) were selected as independent instrumental variables (IVs) from a GWAS study of A...

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Autores principales: Chen, Shuhong, Luo, Xiqing, Zhao, Jiaoshi, Liang, Zhenguo, Gu, Jieruo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708899/
https://www.ncbi.nlm.nih.gov/pubmed/36468019
http://dx.doi.org/10.3389/fgene.2022.951893
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author Chen, Shuhong
Luo, Xiqing
Zhao, Jiaoshi
Liang, Zhenguo
Gu, Jieruo
author_facet Chen, Shuhong
Luo, Xiqing
Zhao, Jiaoshi
Liang, Zhenguo
Gu, Jieruo
author_sort Chen, Shuhong
collection PubMed
description Objective: To study whether ankylosing spondylitis (AS) has a causal effect on the risk of atrial fibrillation (AF) using two-sample Mendelian randomization (MR) analysis. Methods: Single nucleotide polymorphisms (SNPs) were selected as independent instrumental variables (IVs) from a GWAS study of AS. Summary data from a large-scale GWAS meta-analysis of AF was utilized as the outcome dataset. Inverse-variance weighted (IVW) model was used for the primary analysis. Multiple sensitivity and heterogeneity tests were conducted to confirm the robustness of the results. Results: In total, 18 SNPs were identified as IVs for MR analysis. Five MR methods consistently found that ankylosing spondylitis was not causally associated with atrial fibrillation (IVW: OR = 0.983 (0.894, 1.080), p = 0.718; MR-Egger: OR = 1.190 (0.973, 1.456), p = 0.109; Simple mode: OR = 0.888 (0.718, 1.098), p = 0.287; Weighted mode: OR = 0.989 (0.854, 1.147), p = 0.890; Weight median: OR = 0.963 (0.852, 1.088), p = 0.545). Leave-one-out analysis supported the stability of MR results. Both the MR-Egger intercept and MR-PRESSO method revealed the absence of horizontal pleiotropy. Conclusion: The two-sample MR analysis did not support a causal relationship between AS and the risk of AF.
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spelling pubmed-97088992022-12-01 Exploring the causality between ankylosing spondylitis and atrial fibrillation: A two-sample Mendelian randomization study Chen, Shuhong Luo, Xiqing Zhao, Jiaoshi Liang, Zhenguo Gu, Jieruo Front Genet Genetics Objective: To study whether ankylosing spondylitis (AS) has a causal effect on the risk of atrial fibrillation (AF) using two-sample Mendelian randomization (MR) analysis. Methods: Single nucleotide polymorphisms (SNPs) were selected as independent instrumental variables (IVs) from a GWAS study of AS. Summary data from a large-scale GWAS meta-analysis of AF was utilized as the outcome dataset. Inverse-variance weighted (IVW) model was used for the primary analysis. Multiple sensitivity and heterogeneity tests were conducted to confirm the robustness of the results. Results: In total, 18 SNPs were identified as IVs for MR analysis. Five MR methods consistently found that ankylosing spondylitis was not causally associated with atrial fibrillation (IVW: OR = 0.983 (0.894, 1.080), p = 0.718; MR-Egger: OR = 1.190 (0.973, 1.456), p = 0.109; Simple mode: OR = 0.888 (0.718, 1.098), p = 0.287; Weighted mode: OR = 0.989 (0.854, 1.147), p = 0.890; Weight median: OR = 0.963 (0.852, 1.088), p = 0.545). Leave-one-out analysis supported the stability of MR results. Both the MR-Egger intercept and MR-PRESSO method revealed the absence of horizontal pleiotropy. Conclusion: The two-sample MR analysis did not support a causal relationship between AS and the risk of AF. Frontiers Media S.A. 2022-11-16 /pmc/articles/PMC9708899/ /pubmed/36468019 http://dx.doi.org/10.3389/fgene.2022.951893 Text en Copyright © 2022 Chen, Luo, Zhao, Liang and Gu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Chen, Shuhong
Luo, Xiqing
Zhao, Jiaoshi
Liang, Zhenguo
Gu, Jieruo
Exploring the causality between ankylosing spondylitis and atrial fibrillation: A two-sample Mendelian randomization study
title Exploring the causality between ankylosing spondylitis and atrial fibrillation: A two-sample Mendelian randomization study
title_full Exploring the causality between ankylosing spondylitis and atrial fibrillation: A two-sample Mendelian randomization study
title_fullStr Exploring the causality between ankylosing spondylitis and atrial fibrillation: A two-sample Mendelian randomization study
title_full_unstemmed Exploring the causality between ankylosing spondylitis and atrial fibrillation: A two-sample Mendelian randomization study
title_short Exploring the causality between ankylosing spondylitis and atrial fibrillation: A two-sample Mendelian randomization study
title_sort exploring the causality between ankylosing spondylitis and atrial fibrillation: a two-sample mendelian randomization study
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708899/
https://www.ncbi.nlm.nih.gov/pubmed/36468019
http://dx.doi.org/10.3389/fgene.2022.951893
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