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A meta-analysis of the diagnostic utility of biomarkers in cerebrospinal fluid in Parkinson’s disease
Biomarkers play important roles in the diagnosis and differential diagnosis of Parkinson’s disease (PD). Thus, we carried out a systematic review and meta-analysis evaluating the diagnostic utility of cerebrospinal fluid (CSF) biomarkers to distinguish PD from atypical parkinsonian syndromes (APSs)...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709054/ https://www.ncbi.nlm.nih.gov/pubmed/36446820 http://dx.doi.org/10.1038/s41531-022-00431-7 |
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author | Xiang, Chunchen Cong, Shengri Tan, Xiaoping Ma, Shuang Liu, Yang Wang, Hailong Cong, Shuyan |
author_facet | Xiang, Chunchen Cong, Shengri Tan, Xiaoping Ma, Shuang Liu, Yang Wang, Hailong Cong, Shuyan |
author_sort | Xiang, Chunchen |
collection | PubMed |
description | Biomarkers play important roles in the diagnosis and differential diagnosis of Parkinson’s disease (PD). Thus, we carried out a systematic review and meta-analysis evaluating the diagnostic utility of cerebrospinal fluid (CSF) biomarkers to distinguish PD from atypical parkinsonian syndromes (APSs) and controls. Data for PD and APS and controls were extracted from 123 studies that reported the concentration of CSF biomarkers. Comparisons were presented using pooled Hedges’ g. Sources of heterogeneity were evaluated using meta-regression, and subgroup and sensitivity analyses. We found that compared with controls, PD patients had lower levels of amyloid beta 1-42, phosphorylated tau, total tau, total α-synuclein, Zn, DJ-1, and YKL-40, and higher levels of oligomeric and phosphorylated α-synuclein. Moreover, lower CSF levels of neurofilament light chain, t-tau, YKL-40, and C-reactive protein were found in PD patients compared to those with multiple system atrophy. PD patients also had lower levels of NFL and higher levels of Aβ42 compared with patients with progressive supranuclear palsy. Reduced levels of p-tau and t-tau and higher Aβ42 levels were found in PD patients compared with patients with dementia with Lewy bodies. Finally, reduced NFL levels were found in patients with PD compared with patients with cortical basal degeneration. Therefore, we believe that the combinations of t-α-syn, Aβ42, and NFL could be promising biomarkers for the differential diagnosis of PD and APSs. |
format | Online Article Text |
id | pubmed-9709054 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-97090542022-12-01 A meta-analysis of the diagnostic utility of biomarkers in cerebrospinal fluid in Parkinson’s disease Xiang, Chunchen Cong, Shengri Tan, Xiaoping Ma, Shuang Liu, Yang Wang, Hailong Cong, Shuyan NPJ Parkinsons Dis Article Biomarkers play important roles in the diagnosis and differential diagnosis of Parkinson’s disease (PD). Thus, we carried out a systematic review and meta-analysis evaluating the diagnostic utility of cerebrospinal fluid (CSF) biomarkers to distinguish PD from atypical parkinsonian syndromes (APSs) and controls. Data for PD and APS and controls were extracted from 123 studies that reported the concentration of CSF biomarkers. Comparisons were presented using pooled Hedges’ g. Sources of heterogeneity were evaluated using meta-regression, and subgroup and sensitivity analyses. We found that compared with controls, PD patients had lower levels of amyloid beta 1-42, phosphorylated tau, total tau, total α-synuclein, Zn, DJ-1, and YKL-40, and higher levels of oligomeric and phosphorylated α-synuclein. Moreover, lower CSF levels of neurofilament light chain, t-tau, YKL-40, and C-reactive protein were found in PD patients compared to those with multiple system atrophy. PD patients also had lower levels of NFL and higher levels of Aβ42 compared with patients with progressive supranuclear palsy. Reduced levels of p-tau and t-tau and higher Aβ42 levels were found in PD patients compared with patients with dementia with Lewy bodies. Finally, reduced NFL levels were found in patients with PD compared with patients with cortical basal degeneration. Therefore, we believe that the combinations of t-α-syn, Aβ42, and NFL could be promising biomarkers for the differential diagnosis of PD and APSs. Nature Publishing Group UK 2022-11-29 /pmc/articles/PMC9709054/ /pubmed/36446820 http://dx.doi.org/10.1038/s41531-022-00431-7 Text en © The Author(s) 2022, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Xiang, Chunchen Cong, Shengri Tan, Xiaoping Ma, Shuang Liu, Yang Wang, Hailong Cong, Shuyan A meta-analysis of the diagnostic utility of biomarkers in cerebrospinal fluid in Parkinson’s disease |
title | A meta-analysis of the diagnostic utility of biomarkers in cerebrospinal fluid in Parkinson’s disease |
title_full | A meta-analysis of the diagnostic utility of biomarkers in cerebrospinal fluid in Parkinson’s disease |
title_fullStr | A meta-analysis of the diagnostic utility of biomarkers in cerebrospinal fluid in Parkinson’s disease |
title_full_unstemmed | A meta-analysis of the diagnostic utility of biomarkers in cerebrospinal fluid in Parkinson’s disease |
title_short | A meta-analysis of the diagnostic utility of biomarkers in cerebrospinal fluid in Parkinson’s disease |
title_sort | meta-analysis of the diagnostic utility of biomarkers in cerebrospinal fluid in parkinson’s disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709054/ https://www.ncbi.nlm.nih.gov/pubmed/36446820 http://dx.doi.org/10.1038/s41531-022-00431-7 |
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