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HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation

Activation of client protein kinases by the HSP90 molecular chaperone system is affected by phosphorylation at multiple sites on HSP90, the kinase-specific co-chaperone CDC37, and the kinase client itself. Removal of regulatory phosphorylation from client kinases and their release from the HSP90-CDC...

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Detalles Bibliográficos
Autores principales:	Oberoi, Jasmeen, Guiu, Xavi Aran, Outwin, Emily A., Schellenberger, Pascale, Roumeliotis, Theodoros I., Choudhary, Jyoti S., Pearl, Laurence H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709061/ https://www.ncbi.nlm.nih.gov/pubmed/36446791 http://dx.doi.org/10.1038/s41467-022-35143-2

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