A stable, engineered TL1A ligand co-stimulates T cells via specific binding to DR3

TL1A (TNFSF15) is a TNF superfamily ligand which can bind the TNFRSF member death receptor 3 (DR3) on T cells and the soluble decoy receptor DcR3. Engagement of DR3 on CD4+ or CD8+ effector T cells by TL1A induces downstream signaling, leading to proliferation and an increase in secretion of inflamm...

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Detalles Bibliográficos
Autores principales: Zwolak, Adam, Chan, Szeman Ruby, Harvilla, Paul, Mahady, Sally, Armstrong, Anthony A., Luistro, Leopoldo, Tamot, Ninkka, Yamada, Douglas, Derebe, Mehabaw, Pomerantz, Steven, Chiu, Mark, Ganesan, Rajkumar, Chowdhury, Partha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709071/
https://www.ncbi.nlm.nih.gov/pubmed/36446890
http://dx.doi.org/10.1038/s41598-022-24984-y

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