A G-quadruplex stabilizer, CX-5461 combined with two immune checkpoint inhibitors enhances in vivo therapeutic efficacy by increasing PD-L1 expression in colorectal cancer

PURPOSE: Immune checkpoint inhibitors (ICIs) alone or in combination with chemotherapy can improve the limited efficacy of colorectal cancer (CRC) immunotherapy. CX-5461 causes substantial DNA damage and genomic instability and can increase ICIs’ therapeutic efficacies through tumor microenvironment...

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Detalles Bibliográficos
Autores principales: Chung, Shin-Yi, Chang, Yu-Chan, Hsu, Dennis Shin-Shian, Hung, Ya-Chi, Lu, Meng-Lun, Hung, Yi-Ping, Chiang, Nai-Jung, Yeh, Chun-Nan, Hsiao, Michael, Soong, John, Su, Yeu, Chen, Ming-Huang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709093/
https://www.ncbi.nlm.nih.gov/pubmed/36442297
http://dx.doi.org/10.1016/j.neo.2022.100856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709093/
https://www.ncbi.nlm.nih.gov/pubmed/36442297
http://dx.doi.org/10.1016/j.neo.2022.100856

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