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Chronic stress causes striatal disinhibition mediated by SOM-interneurons in male mice
Chronic stress (CS) is associated with a number of neuropsychiatric disorders, and it may also contribute to or exacerbate motor function. However, the mechanisms by which stress triggers motor symptoms are not fully understood. Here, we report that CS functionally alters dorsomedial striatum (DMS)...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709160/ https://www.ncbi.nlm.nih.gov/pubmed/36446783 http://dx.doi.org/10.1038/s41467-022-35028-4 |
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author | Rodrigues, Diana Jacinto, Luis Falcão, Margarida Castro, Ana Carolina Cruz, Alexandra Santa, Cátia Manadas, Bruno Marques, Fernanda Sousa, Nuno Monteiro, Patricia |
author_facet | Rodrigues, Diana Jacinto, Luis Falcão, Margarida Castro, Ana Carolina Cruz, Alexandra Santa, Cátia Manadas, Bruno Marques, Fernanda Sousa, Nuno Monteiro, Patricia |
author_sort | Rodrigues, Diana |
collection | PubMed |
description | Chronic stress (CS) is associated with a number of neuropsychiatric disorders, and it may also contribute to or exacerbate motor function. However, the mechanisms by which stress triggers motor symptoms are not fully understood. Here, we report that CS functionally alters dorsomedial striatum (DMS) circuits in male mice, by affecting GABAergic interneuron populations and somatostatin positive (SOM) interneurons in particular. Specifically, we show that CS impairs communication between SOM interneurons and medium spiny neurons, promoting striatal overactivation/disinhibition and increased motor output. Using probabilistic machine learning to analyze animal behavior, we demonstrate that in vivo chemogenetic manipulation of SOM interneurons in DMS modulates motor phenotypes in stressed mice. Altogether, we propose a causal link between dysfunction of striatal SOM interneurons and motor symptoms in models of chronic stress. |
format | Online Article Text |
id | pubmed-9709160 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-97091602022-12-01 Chronic stress causes striatal disinhibition mediated by SOM-interneurons in male mice Rodrigues, Diana Jacinto, Luis Falcão, Margarida Castro, Ana Carolina Cruz, Alexandra Santa, Cátia Manadas, Bruno Marques, Fernanda Sousa, Nuno Monteiro, Patricia Nat Commun Article Chronic stress (CS) is associated with a number of neuropsychiatric disorders, and it may also contribute to or exacerbate motor function. However, the mechanisms by which stress triggers motor symptoms are not fully understood. Here, we report that CS functionally alters dorsomedial striatum (DMS) circuits in male mice, by affecting GABAergic interneuron populations and somatostatin positive (SOM) interneurons in particular. Specifically, we show that CS impairs communication between SOM interneurons and medium spiny neurons, promoting striatal overactivation/disinhibition and increased motor output. Using probabilistic machine learning to analyze animal behavior, we demonstrate that in vivo chemogenetic manipulation of SOM interneurons in DMS modulates motor phenotypes in stressed mice. Altogether, we propose a causal link between dysfunction of striatal SOM interneurons and motor symptoms in models of chronic stress. Nature Publishing Group UK 2022-11-29 /pmc/articles/PMC9709160/ /pubmed/36446783 http://dx.doi.org/10.1038/s41467-022-35028-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Rodrigues, Diana Jacinto, Luis Falcão, Margarida Castro, Ana Carolina Cruz, Alexandra Santa, Cátia Manadas, Bruno Marques, Fernanda Sousa, Nuno Monteiro, Patricia Chronic stress causes striatal disinhibition mediated by SOM-interneurons in male mice |
title | Chronic stress causes striatal disinhibition mediated by SOM-interneurons in male mice |
title_full | Chronic stress causes striatal disinhibition mediated by SOM-interneurons in male mice |
title_fullStr | Chronic stress causes striatal disinhibition mediated by SOM-interneurons in male mice |
title_full_unstemmed | Chronic stress causes striatal disinhibition mediated by SOM-interneurons in male mice |
title_short | Chronic stress causes striatal disinhibition mediated by SOM-interneurons in male mice |
title_sort | chronic stress causes striatal disinhibition mediated by som-interneurons in male mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709160/ https://www.ncbi.nlm.nih.gov/pubmed/36446783 http://dx.doi.org/10.1038/s41467-022-35028-4 |
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