Mechano-growth factor E-domain modulates cardiac contractile function through 14-3-3 protein interactomes

In the heart, alternative splicing of the igf-I gene produces two isoforms: IGF-IEa and IGF-IEc, (Mechano-growth factor, MGF). The sequence divergence between their E-domain regions suggests differential isoform function. To define the biological actions of MGF’s E-domain, we performed in silico ana...

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Detalles Bibliográficos
Autores principales: Solís, Christopher, Thompson, Walter C., Peña, James R., McDermott-Roe, Christopher, Langa, Paulina, Warren, Chad M., Chrzanowska, Magdalena, Wolska, Beata M., Solaro, R. John, Pieter Detombe, Goldspink, Paul H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709209/
https://www.ncbi.nlm.nih.gov/pubmed/36467694
http://dx.doi.org/10.3389/fphys.2022.1028345

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