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PDZD8-deficient mice accumulate cholesteryl esters in the brain as a result of impaired lipophagy

Dyslipidemia including the accumulation of cholesteryl esters (CEs) in the brain is associated with neurological disorders, although the underlying mechanism has been unclear. PDZD8, a Rab7 effector protein, transfers lipids between endoplasmic reticulum (ER) and Rab7-positive organelles and thereby...

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Detalles Bibliográficos
Autores principales:	Morita, Keiko, Wada, Mariko, Nakatani, Kohta, Matsumoto, Yuki, Hayashi, Nahoki, Yamahata, Ikuko, Mitsunari, Kotone, Mukae, Nagi, Takahashi, Masatomo, Izumi, Yoshihiro, Bamba, Takeshi, Shirane, Michiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709239/ https://www.ncbi.nlm.nih.gov/pubmed/36465123 http://dx.doi.org/10.1016/j.isci.2022.105612

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