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Histones and their chaperones: Adaptive remodelers of an ever-changing chromatinic landscape

Chromatin maintenance and remodeling are processes that take place alongside DNA repair, replication, or transcription to ensure the survival and adaptability of a cell. The environment and the needs of the cell dictate how chromatin is remodeled; particularly where and which histones are deposited,...

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Autores principales: Torres-Arciga, Karla, Flores-León, Manuel, Ruiz-Pérez, Samuel, Trujillo-Pineda, Magalli, González-Barrios, Rodrigo, Herrera, Luis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709290/
https://www.ncbi.nlm.nih.gov/pubmed/36468032
http://dx.doi.org/10.3389/fgene.2022.1057846
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author Torres-Arciga, Karla
Flores-León, Manuel
Ruiz-Pérez, Samuel
Trujillo-Pineda, Magalli
González-Barrios, Rodrigo
Herrera, Luis A.
author_facet Torres-Arciga, Karla
Flores-León, Manuel
Ruiz-Pérez, Samuel
Trujillo-Pineda, Magalli
González-Barrios, Rodrigo
Herrera, Luis A.
author_sort Torres-Arciga, Karla
collection PubMed
description Chromatin maintenance and remodeling are processes that take place alongside DNA repair, replication, or transcription to ensure the survival and adaptability of a cell. The environment and the needs of the cell dictate how chromatin is remodeled; particularly where and which histones are deposited, thus changing the canonical histone array to regulate chromatin structure and gene expression. Chromatin is highly dynamic, and histone variants and their chaperones play a crucial role in maintaining the epigenetic regulation at different genomic regions. Despite the large number of histone variants reported to date, studies on their roles in physiological processes and pathologies are emerging but continue to be scarce. Here, we present recent advances in the research on histone variants and their chaperones, with a focus on their importance in molecular mechanisms such as replication, transcription, and DNA damage repair. Additionally, we discuss the emerging role they have in transposable element regulation, aging, and chromatin remodeling syndromes. Finally, we describe currently used methods and their limitations in the study of these proteins and highlight the importance of improving the experimental approaches to further understand this epigenetic machinery.
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spelling pubmed-97092902022-12-01 Histones and their chaperones: Adaptive remodelers of an ever-changing chromatinic landscape Torres-Arciga, Karla Flores-León, Manuel Ruiz-Pérez, Samuel Trujillo-Pineda, Magalli González-Barrios, Rodrigo Herrera, Luis A. Front Genet Genetics Chromatin maintenance and remodeling are processes that take place alongside DNA repair, replication, or transcription to ensure the survival and adaptability of a cell. The environment and the needs of the cell dictate how chromatin is remodeled; particularly where and which histones are deposited, thus changing the canonical histone array to regulate chromatin structure and gene expression. Chromatin is highly dynamic, and histone variants and their chaperones play a crucial role in maintaining the epigenetic regulation at different genomic regions. Despite the large number of histone variants reported to date, studies on their roles in physiological processes and pathologies are emerging but continue to be scarce. Here, we present recent advances in the research on histone variants and their chaperones, with a focus on their importance in molecular mechanisms such as replication, transcription, and DNA damage repair. Additionally, we discuss the emerging role they have in transposable element regulation, aging, and chromatin remodeling syndromes. Finally, we describe currently used methods and their limitations in the study of these proteins and highlight the importance of improving the experimental approaches to further understand this epigenetic machinery. Frontiers Media S.A. 2022-11-16 /pmc/articles/PMC9709290/ /pubmed/36468032 http://dx.doi.org/10.3389/fgene.2022.1057846 Text en Copyright © 2022 Torres-Arciga, Flores-León, Ruiz-Pérez, Trujillo-Pineda, González-Barrios and Herrera. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Torres-Arciga, Karla
Flores-León, Manuel
Ruiz-Pérez, Samuel
Trujillo-Pineda, Magalli
González-Barrios, Rodrigo
Herrera, Luis A.
Histones and their chaperones: Adaptive remodelers of an ever-changing chromatinic landscape
title Histones and their chaperones: Adaptive remodelers of an ever-changing chromatinic landscape
title_full Histones and their chaperones: Adaptive remodelers of an ever-changing chromatinic landscape
title_fullStr Histones and their chaperones: Adaptive remodelers of an ever-changing chromatinic landscape
title_full_unstemmed Histones and their chaperones: Adaptive remodelers of an ever-changing chromatinic landscape
title_short Histones and their chaperones: Adaptive remodelers of an ever-changing chromatinic landscape
title_sort histones and their chaperones: adaptive remodelers of an ever-changing chromatinic landscape
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709290/
https://www.ncbi.nlm.nih.gov/pubmed/36468032
http://dx.doi.org/10.3389/fgene.2022.1057846
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