NeuroD1 localizes to the presumptive ganglia and gut of the sea urchin larvae

NeuroD is a transcription factor (TF) that plays a dual role in vertebrate neurogenesis and glucose homeostasis in the pancreas. We identified a NeuroD antibody developed against human that cross-reacts with the sea urchin NeuroD1. NeuroD1 protein localizes to the presumptive ganglia and neurofilame...

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Detalles Bibliográficos
Autores principales: Konrad, Kalin D., Song, Jia L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2022
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709636/
https://www.ncbi.nlm.nih.gov/pubmed/36468156
http://dx.doi.org/10.17912/micropub.biology.000682
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author Konrad, Kalin D.
Song, Jia L.
author_facet Konrad, Kalin D.
Song, Jia L.
author_sort Konrad, Kalin D.
collection PubMed
description NeuroD is a transcription factor (TF) that plays a dual role in vertebrate neurogenesis and glucose homeostasis in the pancreas. We identified a NeuroD antibody developed against human that cross-reacts with the sea urchin NeuroD1. NeuroD1 protein localizes to the presumptive ganglia and neurofilament structures in the ciliary band of the sea urchin larvae. In addition, we also observed NeuroD1 in the perinuclear region in the sea urchin gut which is analogous to the mammalian pancreas. These results suggest that NeuroD1 may play an evolutionarily conserved role in the invertebrate sea urchin.
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spelling pubmed-97096362022-12-01 NeuroD1 localizes to the presumptive ganglia and gut of the sea urchin larvae Konrad, Kalin D. Song, Jia L. MicroPubl Biol New Finding NeuroD is a transcription factor (TF) that plays a dual role in vertebrate neurogenesis and glucose homeostasis in the pancreas. We identified a NeuroD antibody developed against human that cross-reacts with the sea urchin NeuroD1. NeuroD1 protein localizes to the presumptive ganglia and neurofilament structures in the ciliary band of the sea urchin larvae. In addition, we also observed NeuroD1 in the perinuclear region in the sea urchin gut which is analogous to the mammalian pancreas. These results suggest that NeuroD1 may play an evolutionarily conserved role in the invertebrate sea urchin. Caltech Library 2022-11-15 /pmc/articles/PMC9709636/ /pubmed/36468156 http://dx.doi.org/10.17912/micropub.biology.000682 Text en Copyright: © 2022 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Konrad, Kalin D.
Song, Jia L.
NeuroD1 localizes to the presumptive ganglia and gut of the sea urchin larvae
title NeuroD1 localizes to the presumptive ganglia and gut of the sea urchin larvae
title_full NeuroD1 localizes to the presumptive ganglia and gut of the sea urchin larvae
title_fullStr NeuroD1 localizes to the presumptive ganglia and gut of the sea urchin larvae
title_full_unstemmed NeuroD1 localizes to the presumptive ganglia and gut of the sea urchin larvae
title_short NeuroD1 localizes to the presumptive ganglia and gut of the sea urchin larvae
title_sort neurod1 localizes to the presumptive ganglia and gut of the sea urchin larvae
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709636/
https://www.ncbi.nlm.nih.gov/pubmed/36468156
http://dx.doi.org/10.17912/micropub.biology.000682
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