An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis

Tumor necrosis factor (TNF) is a pleiotropic cytokine belonging to a family of trimeric proteins with both proinflammatory and immunoregulatory functions. TNF is a key mediator in autoimmune diseases and during the last couple of decades several biologic drugs have delivered new therapeutic options...

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Detalles Bibliográficos
Autores principales: Vugler, Alexander, O’Connell, James, Nguyen, Mai Anh, Weitz, Dietmar, Leeuw, Thomas, Hickford, Elizabeth, Verbitsky, Alexander, Ying, Xiaoyou, Rehberg, Markus, Carrington, Bruce, Merriman, Mark, Moss, Andrew, Nicholas, Jean-Marie, Stanley, Phil, Wright, Sara, Bourne, Tim, Foricher, Yann, Brookings, Daniel, Horsley, Helen, Herrmann, Matthias, Rao, Srinivas, Kohlmann, Markus, Florian, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709720/
https://www.ncbi.nlm.nih.gov/pubmed/36467083
http://dx.doi.org/10.3389/fphar.2022.1037983

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