Photo-induced telomeric DNA damage in human cancer cells

Herein we report on the study of novel dinuclear ruthenium(ii) complexes designed to target and to photo-react with G-quadruplex telomeric DNA. Upon irradiation, complexes efficiently generate guanine radical cation sites as photo-oxidation products. The compounds also display efficient cell penetra...

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Detalles Bibliográficos
Autores principales: Weynand, Justin, Episkopou, Harikleia, Le Berre, Gabriel, Gillard, Martin, Dejeu, Jérôme, Decottignies, Anabelle, Defrancq, Eric, Elias, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709782/
https://www.ncbi.nlm.nih.gov/pubmed/36544575
http://dx.doi.org/10.1039/d2cb00192f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709782/
https://www.ncbi.nlm.nih.gov/pubmed/36544575
http://dx.doi.org/10.1039/d2cb00192f

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