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Human milk nutritional composition across lactational stages in Central Africa

The African region encompasses the highest undernutrition burden with the highest neonatal and infant mortality rates globally. Under these circumstances, breastfeeding is one of the most effective ways to ensure child health and development. However, evidence on human milk (HM) composition from Afr...

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Autores principales: Moya-Alvarez, Violeta, Eussen, Simone R. B. M., Mank, Marko, Koyembi, Jean-Christophe Junior, Nyasenu, Yawo Tufa, Ngaya, Gilles, Mad-Bondo, Daniel, Kongoma, Jean-Bertrand, Stahl, Bernd, Sansonetti, Philippe J., Bourdet-Sicard, Raphaëlle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709887/
https://www.ncbi.nlm.nih.gov/pubmed/36466422
http://dx.doi.org/10.3389/fnut.2022.1033005
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author Moya-Alvarez, Violeta
Eussen, Simone R. B. M.
Mank, Marko
Koyembi, Jean-Christophe Junior
Nyasenu, Yawo Tufa
Ngaya, Gilles
Mad-Bondo, Daniel
Kongoma, Jean-Bertrand
Stahl, Bernd
Sansonetti, Philippe J.
Bourdet-Sicard, Raphaëlle
author_facet Moya-Alvarez, Violeta
Eussen, Simone R. B. M.
Mank, Marko
Koyembi, Jean-Christophe Junior
Nyasenu, Yawo Tufa
Ngaya, Gilles
Mad-Bondo, Daniel
Kongoma, Jean-Bertrand
Stahl, Bernd
Sansonetti, Philippe J.
Bourdet-Sicard, Raphaëlle
author_sort Moya-Alvarez, Violeta
collection PubMed
description The African region encompasses the highest undernutrition burden with the highest neonatal and infant mortality rates globally. Under these circumstances, breastfeeding is one of the most effective ways to ensure child health and development. However, evidence on human milk (HM) composition from African women is scarce. This is of special concern, as we have no reference data from HM composition in the context of food insecurity in Africa. Furthermore, data on the evolution of HM across lactational stages in this setting lack as well. In the MITICA study, we conducted a cohort study among 48 Central-African women and their 50 infants to analyze the emergence of gut dysbiosis in infants and describe the mother-infant transmission of microbiota between birth and 6 months of age. In this context, we assessed nutritional components in HM of 48 lactating women in Central Africa through five sampling times from week 1 after birth until week 25. Unexpectedly, HM-type III (Secretor + and Lewis genes -) was predominant in HM from Central African women, and some nutrients differed significantly among HM-types. While lactose concentration increased across lactation periods, fatty acid concentration did not vary significantly. The overall median level of 16 detected individual human milk oligosaccharides (HMOs; core structures as well as fucosylated and sialylated ones) decreased from 7.3 g/l at week 1 to 3.5 g/l at week 25. The median levels of total amino acids in HM dropped from 12.8 mg/ml at week 1 to 7.4 mg/ml at week 25. In contrast, specific free amino acids increased between months 1 and 3 of lactation, e.g., free glutamic acid, glutamine, aspartic acid, and serine. In conclusion, HM-type distribution and certain nutrients differed from Western mother HM.
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spelling pubmed-97098872022-12-01 Human milk nutritional composition across lactational stages in Central Africa Moya-Alvarez, Violeta Eussen, Simone R. B. M. Mank, Marko Koyembi, Jean-Christophe Junior Nyasenu, Yawo Tufa Ngaya, Gilles Mad-Bondo, Daniel Kongoma, Jean-Bertrand Stahl, Bernd Sansonetti, Philippe J. Bourdet-Sicard, Raphaëlle Front Nutr Nutrition The African region encompasses the highest undernutrition burden with the highest neonatal and infant mortality rates globally. Under these circumstances, breastfeeding is one of the most effective ways to ensure child health and development. However, evidence on human milk (HM) composition from African women is scarce. This is of special concern, as we have no reference data from HM composition in the context of food insecurity in Africa. Furthermore, data on the evolution of HM across lactational stages in this setting lack as well. In the MITICA study, we conducted a cohort study among 48 Central-African women and their 50 infants to analyze the emergence of gut dysbiosis in infants and describe the mother-infant transmission of microbiota between birth and 6 months of age. In this context, we assessed nutritional components in HM of 48 lactating women in Central Africa through five sampling times from week 1 after birth until week 25. Unexpectedly, HM-type III (Secretor + and Lewis genes -) was predominant in HM from Central African women, and some nutrients differed significantly among HM-types. While lactose concentration increased across lactation periods, fatty acid concentration did not vary significantly. The overall median level of 16 detected individual human milk oligosaccharides (HMOs; core structures as well as fucosylated and sialylated ones) decreased from 7.3 g/l at week 1 to 3.5 g/l at week 25. The median levels of total amino acids in HM dropped from 12.8 mg/ml at week 1 to 7.4 mg/ml at week 25. In contrast, specific free amino acids increased between months 1 and 3 of lactation, e.g., free glutamic acid, glutamine, aspartic acid, and serine. In conclusion, HM-type distribution and certain nutrients differed from Western mother HM. Frontiers Media S.A. 2022-11-16 /pmc/articles/PMC9709887/ /pubmed/36466422 http://dx.doi.org/10.3389/fnut.2022.1033005 Text en Copyright © 2022 Moya-Alvarez, Eussen, Mank, Koyembi, Nyasenu, Ngaya, Mad-Bondo, Kongoma, Stahl, Sansonetti and Bourdet-Sicard. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Moya-Alvarez, Violeta
Eussen, Simone R. B. M.
Mank, Marko
Koyembi, Jean-Christophe Junior
Nyasenu, Yawo Tufa
Ngaya, Gilles
Mad-Bondo, Daniel
Kongoma, Jean-Bertrand
Stahl, Bernd
Sansonetti, Philippe J.
Bourdet-Sicard, Raphaëlle
Human milk nutritional composition across lactational stages in Central Africa
title Human milk nutritional composition across lactational stages in Central Africa
title_full Human milk nutritional composition across lactational stages in Central Africa
title_fullStr Human milk nutritional composition across lactational stages in Central Africa
title_full_unstemmed Human milk nutritional composition across lactational stages in Central Africa
title_short Human milk nutritional composition across lactational stages in Central Africa
title_sort human milk nutritional composition across lactational stages in central africa
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709887/
https://www.ncbi.nlm.nih.gov/pubmed/36466422
http://dx.doi.org/10.3389/fnut.2022.1033005
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