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Abnormal resting-state functional connectivity of the insula in medication-free patients with obsessive-compulsive disorder
BACKGROUND: The function of the insula has been increasingly mentioned in neurocircuitry models of obsessive-compulsive disorder (OCD) for its role in affective processing and regulating anxiety and its wide interactions with the classic cortico-striato-thalamo-cortical circuit. However, the insular...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710058/ https://www.ncbi.nlm.nih.gov/pubmed/36447147 http://dx.doi.org/10.1186/s12888-022-04341-z |
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author | Zhou, Zilin Li, Bin Jiang, Jiaxin Li, Hailong Cao, Lingxiao Zhang, Suming Gao, Yingxue Zhang, Lianqing Qiu, Changjian Huang, Xiaoqi Gong, Qiyong |
author_facet | Zhou, Zilin Li, Bin Jiang, Jiaxin Li, Hailong Cao, Lingxiao Zhang, Suming Gao, Yingxue Zhang, Lianqing Qiu, Changjian Huang, Xiaoqi Gong, Qiyong |
author_sort | Zhou, Zilin |
collection | PubMed |
description | BACKGROUND: The function of the insula has been increasingly mentioned in neurocircuitry models of obsessive-compulsive disorder (OCD) for its role in affective processing and regulating anxiety and its wide interactions with the classic cortico-striato-thalamo-cortical circuit. However, the insular resting-state functional connectivity patterns in OCD remain unclear. Therefore, we aimed to investigate characteristic intrinsic connectivity alterations of the insula in OCD and their associations with clinical features. METHODS: We obtained resting-state functional magnetic resonance imaging data from 85 drug-free OCD patients and 85 age- and sex-matched healthy controls (HCs). We performed a general linear model to compare the whole-brain intrinsic functional connectivity maps of the bilateral insula between the OCD and HC groups. In addition, we further explored the relationship between the intrinsic functional connectivity alterations of the insula and clinical features using Pearson or Spearman correlation analysis. RESULTS: Compared with HCs, patients with OCD exhibited increased intrinsic connectivity between the bilateral insula and bilateral precuneus gyrus extending to the inferior parietal lobule and supplementary motor area. Decreased intrinsic connectivity was only found between the right insula and bilateral lingual gyrus in OCD patients relative to HC subjects, which was negatively correlated with the severity of depression symptoms in the OCD group. CONCLUSION: In the current study, we identified impaired insular intrinsic connectivity in OCD patients and the dysconnectivity of the right insula and bilateral lingual gyrus associated with the depressive severity of OCD patients. These findings provide neuroimaging evidence for the involvement of the insula in OCD and suggest its potential role in the depressive symptoms of OCD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12888-022-04341-z. |
format | Online Article Text |
id | pubmed-9710058 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-97100582022-12-01 Abnormal resting-state functional connectivity of the insula in medication-free patients with obsessive-compulsive disorder Zhou, Zilin Li, Bin Jiang, Jiaxin Li, Hailong Cao, Lingxiao Zhang, Suming Gao, Yingxue Zhang, Lianqing Qiu, Changjian Huang, Xiaoqi Gong, Qiyong BMC Psychiatry Research BACKGROUND: The function of the insula has been increasingly mentioned in neurocircuitry models of obsessive-compulsive disorder (OCD) for its role in affective processing and regulating anxiety and its wide interactions with the classic cortico-striato-thalamo-cortical circuit. However, the insular resting-state functional connectivity patterns in OCD remain unclear. Therefore, we aimed to investigate characteristic intrinsic connectivity alterations of the insula in OCD and their associations with clinical features. METHODS: We obtained resting-state functional magnetic resonance imaging data from 85 drug-free OCD patients and 85 age- and sex-matched healthy controls (HCs). We performed a general linear model to compare the whole-brain intrinsic functional connectivity maps of the bilateral insula between the OCD and HC groups. In addition, we further explored the relationship between the intrinsic functional connectivity alterations of the insula and clinical features using Pearson or Spearman correlation analysis. RESULTS: Compared with HCs, patients with OCD exhibited increased intrinsic connectivity between the bilateral insula and bilateral precuneus gyrus extending to the inferior parietal lobule and supplementary motor area. Decreased intrinsic connectivity was only found between the right insula and bilateral lingual gyrus in OCD patients relative to HC subjects, which was negatively correlated with the severity of depression symptoms in the OCD group. CONCLUSION: In the current study, we identified impaired insular intrinsic connectivity in OCD patients and the dysconnectivity of the right insula and bilateral lingual gyrus associated with the depressive severity of OCD patients. These findings provide neuroimaging evidence for the involvement of the insula in OCD and suggest its potential role in the depressive symptoms of OCD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12888-022-04341-z. BioMed Central 2022-11-29 /pmc/articles/PMC9710058/ /pubmed/36447147 http://dx.doi.org/10.1186/s12888-022-04341-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Zhou, Zilin Li, Bin Jiang, Jiaxin Li, Hailong Cao, Lingxiao Zhang, Suming Gao, Yingxue Zhang, Lianqing Qiu, Changjian Huang, Xiaoqi Gong, Qiyong Abnormal resting-state functional connectivity of the insula in medication-free patients with obsessive-compulsive disorder |
title | Abnormal resting-state functional connectivity of the insula in medication-free patients with obsessive-compulsive disorder |
title_full | Abnormal resting-state functional connectivity of the insula in medication-free patients with obsessive-compulsive disorder |
title_fullStr | Abnormal resting-state functional connectivity of the insula in medication-free patients with obsessive-compulsive disorder |
title_full_unstemmed | Abnormal resting-state functional connectivity of the insula in medication-free patients with obsessive-compulsive disorder |
title_short | Abnormal resting-state functional connectivity of the insula in medication-free patients with obsessive-compulsive disorder |
title_sort | abnormal resting-state functional connectivity of the insula in medication-free patients with obsessive-compulsive disorder |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710058/ https://www.ncbi.nlm.nih.gov/pubmed/36447147 http://dx.doi.org/10.1186/s12888-022-04341-z |
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