Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice

Dopamine-deficient (DD) mice exhibit psychomotor hyperactivity that might be related to a decrease in muscarinic signaling. In the present study, muscarinic acetylcholine receptor M2 (CHRM2) density decreased in the cortex in DD mice. This is significant because cortical CHRM2 acts as an autorecepto...

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Detalles Bibliográficos
Autores principales: Fujita, Masayo, Ochiai, Yukiko, Hagino, Yoko, Kobayashi, Kazuto, Pavey, Geoffrey, Dean, Brian, Ikeda, Kazutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Micro Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710075/
https://www.ncbi.nlm.nih.gov/pubmed/36447257
http://dx.doi.org/10.1186/s13041-022-00984-x
Descripción
Sumario:Dopamine-deficient (DD) mice exhibit psychomotor hyperactivity that might be related to a decrease in muscarinic signaling. In the present study, muscarinic acetylcholine receptor M2 (CHRM2) density decreased in the cortex in DD mice. This is significant because cortical CHRM2 acts as an autoreceptor; therefore, changes in CHRM2 levels could alter acetylcholine in DD mice. We also found that the CHRM1/CHRM4 agonist xanomeline and CHRM2 agonist arecaidine propargyl ester tosylate inhibited hyperactivity in DD mice, suggesting that postsynaptic CHRM1 and CHRM2 and presynaptic CHRM2 may be involved in hyperactivity in DD mice. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13041-022-00984-x.

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