Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice

Dopamine-deficient (DD) mice exhibit psychomotor hyperactivity that might be related to a decrease in muscarinic signaling. In the present study, muscarinic acetylcholine receptor M2 (CHRM2) density decreased in the cortex in DD mice. This is significant because cortical CHRM2 acts as an autorecepto...

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Autores principales: Fujita, Masayo, Ochiai, Yukiko, Hagino, Yoko, Kobayashi, Kazuto, Pavey, Geoffrey, Dean, Brian, Ikeda, Kazutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Micro Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710075/
https://www.ncbi.nlm.nih.gov/pubmed/36447257
http://dx.doi.org/10.1186/s13041-022-00984-x
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author Fujita, Masayo
Ochiai, Yukiko
Hagino, Yoko
Kobayashi, Kazuto
Pavey, Geoffrey
Dean, Brian
Ikeda, Kazutaka
author_facet Fujita, Masayo
Ochiai, Yukiko
Hagino, Yoko
Kobayashi, Kazuto
Pavey, Geoffrey
Dean, Brian
Ikeda, Kazutaka
author_sort Fujita, Masayo
collection PubMed
description Dopamine-deficient (DD) mice exhibit psychomotor hyperactivity that might be related to a decrease in muscarinic signaling. In the present study, muscarinic acetylcholine receptor M2 (CHRM2) density decreased in the cortex in DD mice. This is significant because cortical CHRM2 acts as an autoreceptor; therefore, changes in CHRM2 levels could alter acetylcholine in DD mice. We also found that the CHRM1/CHRM4 agonist xanomeline and CHRM2 agonist arecaidine propargyl ester tosylate inhibited hyperactivity in DD mice, suggesting that postsynaptic CHRM1 and CHRM2 and presynaptic CHRM2 may be involved in hyperactivity in DD mice. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13041-022-00984-x.
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spelling pubmed-97100752022-12-01 Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice Fujita, Masayo Ochiai, Yukiko Hagino, Yoko Kobayashi, Kazuto Pavey, Geoffrey Dean, Brian Ikeda, Kazutaka Mol Brain Micro Report Dopamine-deficient (DD) mice exhibit psychomotor hyperactivity that might be related to a decrease in muscarinic signaling. In the present study, muscarinic acetylcholine receptor M2 (CHRM2) density decreased in the cortex in DD mice. This is significant because cortical CHRM2 acts as an autoreceptor; therefore, changes in CHRM2 levels could alter acetylcholine in DD mice. We also found that the CHRM1/CHRM4 agonist xanomeline and CHRM2 agonist arecaidine propargyl ester tosylate inhibited hyperactivity in DD mice, suggesting that postsynaptic CHRM1 and CHRM2 and presynaptic CHRM2 may be involved in hyperactivity in DD mice. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13041-022-00984-x. BioMed Central 2022-11-29 /pmc/articles/PMC9710075/ /pubmed/36447257 http://dx.doi.org/10.1186/s13041-022-00984-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Micro Report
Fujita, Masayo
Ochiai, Yukiko
Hagino, Yoko
Kobayashi, Kazuto
Pavey, Geoffrey
Dean, Brian
Ikeda, Kazutaka
Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice
title Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice
title_full Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice
title_fullStr Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice
title_full_unstemmed Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice
title_short Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice
title_sort involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice
topic Micro Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710075/
https://www.ncbi.nlm.nih.gov/pubmed/36447257
http://dx.doi.org/10.1186/s13041-022-00984-x
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