2D and 3D cultured human umbilical cord-derived mesenchymal stem cell-conditioned medium has a dual effect in type 1 diabetes model in rats: immunomodulation and beta-cell regeneration

BACKGROUND: Type 1 diabetes (T1D) is a T-cell-mediated autoimmune disease characterized by the irreversible destruction of insulin-producing β-cells in pancreatic islets. Helper and cytotoxic T-cells and cytokine production, which is impaired by this process, take a synergetic role in β-cell destruc...

Descripción completa

Detalles Bibliográficos
Autores principales: Isildar, Basak, Ozkan, Serbay, Ercin, Merve, Gezginci-Oktayoglu, Selda, Oncul, Mahmut, Koyuturk, Meral
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710085/
https://www.ncbi.nlm.nih.gov/pubmed/36451229
http://dx.doi.org/10.1186/s41232-022-00241-7

Ejemplares similares

Ejemplares similares