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Riluzole partially restores RNA polymerase III complex assembly in cells expressing the leukodystrophy-causative variant POLR3B R103H

The mechanism of assembly of RNA polymerase III (Pol III), the 17-subunit enzyme that synthesizes tRNAs, 5 S rRNA, and other small-nuclear (sn) RNAs in eukaryotes, is not clearly understood. The recent discovery of the HSP90 co-chaperone PAQosome (Particle for Arrangement of Quaternary structure) re...

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Detalles Bibliográficos
Autores principales:	Pinard, Maxime, Dastpeyman, Samaneh, Poitras, Christian, Bernard, Geneviève, Gauthier, Marie-Soleil, Coulombe, Benoit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710144/ https://www.ncbi.nlm.nih.gov/pubmed/36451185 http://dx.doi.org/10.1186/s13041-022-00974-z

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