Cargando…

β-Synuclein as a candidate blood biomarker for synaptic degeneration in Alzheimer’s disease

Synaptic degeneration is an early event closely associated with the course of Alzheimer’s disease (AD). The identification of synaptic blood biomarkers is, therefore, of great interest and clinical relevance. The levels of most synaptic proteins are increased in the cerebrospinal fluid (CSF) of pati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mohaupt, Pablo, Pons, Marie-Laure, Vialaret, Jérôme, Delaby, Constance, Hirtz, Christophe, Lehmann, Sylvain
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Mini Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710176/ https://www.ncbi.nlm.nih.gov/pubmed/36451155 http://dx.doi.org/10.1186/s13195-022-01125-1

Ejemplares similares

Readthrough isoform of aquaporin-4 (AQP4) as a therapeutic target for Alzheimer’s disease and other proteinopathies
por: Mohaupt, Pablo, et al.
Publicado: (2023)

The alternative proteome in neurobiology
por: Mohaupt, Pablo, et al.
Publicado: (2022)

Proteomics Challenges for the Assessment of Synuclein Proteoforms as Clinical Biomarkers in Parkinson’s Disease
por: Pons, Marie-Laure, et al.
Publicado: (2022)

Blood amyloid and tau biomarkers as predictors of cerebrospinal fluid profiles
por: Delaby, Constance, et al.
Publicado: (2022)

Hepcidin and ferritin levels in restless legs syndrome: a case–control study
por: Chenini, Sofiene, et al.
Publicado: (2020)

Comparison of ultrasensitive and mass spectrometry quantification of blood-based amyloid biomarkers for Alzheimer’s disease diagnosis in a memory clinic cohort
por: Hirtz, Christophe, et al.
Publicado: (2023)

From radioimmunoassay to mass spectrometry: a new method to quantify orexin-A (hypocretin-1) in cerebrospinal fluid
por: Hirtz, Christophe, et al.
Publicado: (2016)

Cerebrospinal fluid A beta 1–40 peptides increase in Alzheimer’s disease and are highly correlated with phospho-tau in control individuals
por: Lehmann, Sylvain, et al.
Publicado: (2020)

Antibody-free quantification of seven tau peptides in human CSF using targeted mass spectrometry
por: Bros, Pauline, et al.
Publicado: (2015)

Identification of multiple proteoforms biomarkers on clinical samples by routine Top-Down approaches
por: Vialaret, Jerome, et al.
Publicado: (2018)

The ubiquitin proteasome system in synaptic and axonal degeneration: a new twist to an old cycle
por: Korhonen, Laura, et al.
Publicado: (2004)

Central Nervous System and Peripheral Inflammatory Processes in Alzheimer’s Disease: Biomarker Profiling Approach
por: Delaby, Constance, et al.
Publicado: (2015)

Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease
por: Sharma, Shiv K.
Publicado: (2010)

Neurofilament-Light, a Promising Biomarker: Analytical, Metrological and Clinical Challenges
por: Coppens, Salomé, et al.
Publicado: (2023)

Data from a targeted proteomics approach to discover biomarkers in saliva for the clinical diagnosis of periodontitis
por: Orti, V., et al.
Publicado: (2018)

Editorial: Proteomics as a Tool for Biomarker and Drug Target Discovery: Improving the Diagnosis and Treatment of Neurodegenerative Diseases
por: Belbin, Olivia, et al.
Publicado: (2020)

Parallel mechanisms for direct and indirect membrane protein trafficking by synucleins
por: Oaks, Adam W, et al.
Publicado: (2013)

Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer’s disease and PET amyloid-positive patient identification
por: Barthélemy, Nicolas R., et al.
Publicado: (2020)

Peripheral Blood and Salivary Biomarkers of Blood–Brain Barrier Permeability and Neuronal Damage: Clinical and Applied Concepts
por: Janigro, Damir, et al.
Publicado: (2021)

NFL strongly correlates with TNF-R1 in the plasma of AD patients, but not with cognitive decline
por: Delaby, Constance, et al.
Publicado: (2021)

New Perspectives of Multiplex Mass Spectrometry Blood Protein Quantification on Microsamples in Biological Monitoring of Elderly Patients
por: Vialaret, Jérôme, et al.
Publicado: (2023)

What’s to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?
por: Dunning, Christopher J.R., et al.
Publicado: (2013)

Dysfunctional Mitochondrial Bioenergetics and Synaptic Degeneration in Alzheimer Disease
por: Tang, Jason, et al.
Publicado: (2019)

The Synaptic Function of α-Synuclein
por: Burré, Jacqueline
Publicado: (2015)

Signalled roads to memory and its degeneration
por: Bhat, Priyanka, et al.
Publicado: (2012)

Late-onset behavioral variant of frontotemporal lobar degeneration versus Alzheimer's disease: Interest of cerebrospinal fluid biomarker ratios
por: Marelli, Cecilia, et al.
Publicado: (2015)

The phenomenon of strain degeneration in biotechnologically relevant fungi
por: Danner, Caroline, et al.
Publicado: (2023)

Peripheral inflammatory biomarkers in Alzheimer’s disease: a brief review
por: Park, Jong-Chan, et al.
Publicado: (2020)

Modeling of Tau-Mediated Synaptic and Neuronal Degeneration in Alzheimer's Disease
por: Jaworski, Tomasz, et al.
Publicado: (2010)

The mechanism of degeneration of striatal neuronal subtypes in Huntington disease
por: Rikani, Azadeh A., et al.
Publicado: (2014)

Far from home: the role of glial mRNA localization in synaptic plasticity
por: Gala, Dalia S., et al.
Publicado: (2023)

Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins
por: Carnazza, Kathryn E., et al.
Publicado: (2022)

Corticosteroid Regulation of Synaptic Plasticity in the Hippocampus
por: Maggio, Nicola, et al.
Publicado: (2010)

Sample Pooling and Inflammation Linked to the False Selection of Biomarkers for Neurodegenerative Diseases in Top–Down Proteomics: A Pilot Study
por: Molinari, Nicolas, et al.
Publicado: (2018)

Protein Tau: Prime Cause of Synaptic and Neuronal Degeneration in Alzheimer's Disease
por: Crespo-Biel, Natalia, et al.
Publicado: (2012)

Plant associated protists—Untapped promising candidates for agrifood tools
por: Nguyen, Bao‐Anh Thi, et al.
Publicado: (2022)

Relevance of Aβ42/40 Ratio for Detection of Alzheimer Disease Pathology in Clinical Routine: The PLM(R) Scale
por: Lehmann, Sylvain, et al.
Publicado: (2018)

Role of post-translational modifications on the alpha-synuclein aggregation-related pathogenesis of Parkinson’s disease
por: Yoo, Hajung, et al.
Publicado: (2022)

A paradigm shift in pharmacogenomics: From candidate polymorphisms to comprehensive sequencing
por: Zhou, Yitian, et al.
Publicado: (2022)

Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain
por: Ferreira, Nelson, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7uahmsbftv9oeqa87ag50chmc8