The emerging roles of N(6)-methyladenosine in osteoarthritis

Finding new biomarkers and molecular targets to guide OA treatment remains a significant challenge. One of the most frequent forms of RNA methylation, N(6)-methyladenosine (m(6)A), can affect gene expression and RNA transcription, processing, translation, and metabolism. Osteoarthritis (OA) can cause disability and pain degenerative disease, reduce the quality of life of the elderly, and increase the social and economic burden. Changes in m(6)A levels are crucial in OA progress. In this review, the discussion will concentrate on the role that m(6)A plays in OA occurrence and progression. The m(6)A involved in the OA process mainly includes METTL3 and FTO. Current studies on m(6)A and OA primarily focus on four signaling pathways, namely, NF-κB, LNCRNAs, ATG7, and Bcl2. m(6)A participates in these signaling pathways and affects cellular inflammation, apoptosis, senescence, and autophagy, thus controlling the OA process. The modification of m(6)A affects so many signaling pathways. For the treatment of OA, it may represent a viable new therapeutic target.