The diagnostic potential of novel biomarkers of hypertension in men

INTRODUCTION: The present study aimed to evaluate the diagnostic usefulness of selected novel parameters as biomarkers of hypertension: miR-145-5p, miR-1-3p, miR-423-5p, PCSK9, MyBPC3, NOX1, and CYBb, and NCF2, DNase 1, anti-MPO and anti-PR3 antibodies. METHODS: We present the data of men with norma...

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Detalles Bibliográficos
Autores principales: Charkiewicz, Angelika E., Garley, Marzena, Ratajczak-Wrona, Wioletta, Jabłońska, Ewa, Miltyk, Wojciech, Motyka, Joanna, Omeljaniuk, Wioleta J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2022
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710276/
https://www.ncbi.nlm.nih.gov/pubmed/36457990
http://dx.doi.org/10.5114/aoms/153500
Descripción
Sumario:INTRODUCTION: The present study aimed to evaluate the diagnostic usefulness of selected novel parameters as biomarkers of hypertension: miR-145-5p, miR-1-3p, miR-423-5p, PCSK9, MyBPC3, NOX1, and CYBb, and NCF2, DNase 1, anti-MPO and anti-PR3 antibodies. METHODS: We present the data of men with normal blood pressure, diagnosed hypertension, confirmed hypertension, and hypertension and coexisting coronary artery disease. RESULTS: Elevated levels of miR-145-5p, miR-1-3p, and miR-423-5p and high levels of PCSK9, MyBPC3, and DNase 1 were observed in all groups of hypertensive men. We showed decreased levels of NOX1 and CYBb, and an elevated level of NCF2. CONCLUSIONS: PCSK9 shows the greatest potential as an early biomarker of screening-detected hypertension.

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