The diagnostic potential of novel biomarkers of hypertension in men

INTRODUCTION: The present study aimed to evaluate the diagnostic usefulness of selected novel parameters as biomarkers of hypertension: miR-145-5p, miR-1-3p, miR-423-5p, PCSK9, MyBPC3, NOX1, and CYBb, and NCF2, DNase 1, anti-MPO and anti-PR3 antibodies. METHODS: We present the data of men with norma...

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Autores principales: Charkiewicz, Angelika E., Garley, Marzena, Ratajczak-Wrona, Wioletta, Jabłońska, Ewa, Miltyk, Wojciech, Motyka, Joanna, Omeljaniuk, Wioleta J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2022
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710276/
https://www.ncbi.nlm.nih.gov/pubmed/36457990
http://dx.doi.org/10.5114/aoms/153500
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author Charkiewicz, Angelika E.
Garley, Marzena
Ratajczak-Wrona, Wioletta
Jabłońska, Ewa
Miltyk, Wojciech
Motyka, Joanna
Omeljaniuk, Wioleta J.
author_facet Charkiewicz, Angelika E.
Garley, Marzena
Ratajczak-Wrona, Wioletta
Jabłońska, Ewa
Miltyk, Wojciech
Motyka, Joanna
Omeljaniuk, Wioleta J.
author_sort Charkiewicz, Angelika E.
collection PubMed
description INTRODUCTION: The present study aimed to evaluate the diagnostic usefulness of selected novel parameters as biomarkers of hypertension: miR-145-5p, miR-1-3p, miR-423-5p, PCSK9, MyBPC3, NOX1, and CYBb, and NCF2, DNase 1, anti-MPO and anti-PR3 antibodies. METHODS: We present the data of men with normal blood pressure, diagnosed hypertension, confirmed hypertension, and hypertension and coexisting coronary artery disease. RESULTS: Elevated levels of miR-145-5p, miR-1-3p, and miR-423-5p and high levels of PCSK9, MyBPC3, and DNase 1 were observed in all groups of hypertensive men. We showed decreased levels of NOX1 and CYBb, and an elevated level of NCF2. CONCLUSIONS: PCSK9 shows the greatest potential as an early biomarker of screening-detected hypertension.
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spelling pubmed-97102762022-11-30 The diagnostic potential of novel biomarkers of hypertension in men Charkiewicz, Angelika E. Garley, Marzena Ratajczak-Wrona, Wioletta Jabłońska, Ewa Miltyk, Wojciech Motyka, Joanna Omeljaniuk, Wioleta J. Arch Med Sci Research Letter INTRODUCTION: The present study aimed to evaluate the diagnostic usefulness of selected novel parameters as biomarkers of hypertension: miR-145-5p, miR-1-3p, miR-423-5p, PCSK9, MyBPC3, NOX1, and CYBb, and NCF2, DNase 1, anti-MPO and anti-PR3 antibodies. METHODS: We present the data of men with normal blood pressure, diagnosed hypertension, confirmed hypertension, and hypertension and coexisting coronary artery disease. RESULTS: Elevated levels of miR-145-5p, miR-1-3p, and miR-423-5p and high levels of PCSK9, MyBPC3, and DNase 1 were observed in all groups of hypertensive men. We showed decreased levels of NOX1 and CYBb, and an elevated level of NCF2. CONCLUSIONS: PCSK9 shows the greatest potential as an early biomarker of screening-detected hypertension. Termedia Publishing House 2022-11-07 /pmc/articles/PMC9710276/ /pubmed/36457990 http://dx.doi.org/10.5114/aoms/153500 Text en Copyright: © 2022 Termedia & Banach https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Research Letter
Charkiewicz, Angelika E.
Garley, Marzena
Ratajczak-Wrona, Wioletta
Jabłońska, Ewa
Miltyk, Wojciech
Motyka, Joanna
Omeljaniuk, Wioleta J.
The diagnostic potential of novel biomarkers of hypertension in men
title The diagnostic potential of novel biomarkers of hypertension in men
title_full The diagnostic potential of novel biomarkers of hypertension in men
title_fullStr The diagnostic potential of novel biomarkers of hypertension in men
title_full_unstemmed The diagnostic potential of novel biomarkers of hypertension in men
title_short The diagnostic potential of novel biomarkers of hypertension in men
title_sort diagnostic potential of novel biomarkers of hypertension in men
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710276/
https://www.ncbi.nlm.nih.gov/pubmed/36457990
http://dx.doi.org/10.5114/aoms/153500
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