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Feasibility, safety and tolerability of the CREB-binding protein/β-catenin inhibitor OP-724 in patients with advanced primary biliary cholangitis: an investigator-initiated, open-label, non-randomised, two-centre, phase 1 study
OBJECTIVE: This study aimed to evaluate the safety and tolerability of OP-724, a CREB-binding protein/β-catenin inhibitor, in patients with advanced primary biliary cholangitis (PBC). DESIGN: An open-label, non-randomised, phase 1 trial was conducted at two hospitals in Japan. Patients with advanced...
Autores principales: | Kimura, Masamichi, Ogawa, Eiichi, Harada, Kenichi, Imamura, Jun, Saio, Masanao, Ikura, Yoshihiro, Yatsuhashi, Hiroshi, Murata, Kazumoto, Miura, Kouichi, Ieiri, Ichiro, Tanaka, Atsushi, Kimura, Kiminori |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710334/ https://www.ncbi.nlm.nih.gov/pubmed/36442892 http://dx.doi.org/10.1136/bmjgast-2022-001001 |
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