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Vitamin D status in children and its association with glucose metabolism in northern China: a combination of a cross-sectional and retrospective study

OBJECTIVES: This study aimed to explore the vitamin D status of children in northern China and the association between vitamin D and glucose metabolism. DESIGN: Cross-sectional study was conducted among child participants and retrospective study designs were conducted among adult participants. SETTI...

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Autores principales: Liu, Junyi, Fu, Liqun, Jin, Shanshan, Jia, Yubing, Zhang, Jingyi, Sun, Changhao, Na, Lixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710338/
https://www.ncbi.nlm.nih.gov/pubmed/36446458
http://dx.doi.org/10.1136/bmjopen-2022-061146
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author Liu, Junyi
Fu, Liqun
Jin, Shanshan
Jia, Yubing
Zhang, Jingyi
Sun, Changhao
Na, Lixin
author_facet Liu, Junyi
Fu, Liqun
Jin, Shanshan
Jia, Yubing
Zhang, Jingyi
Sun, Changhao
Na, Lixin
author_sort Liu, Junyi
collection PubMed
description OBJECTIVES: This study aimed to explore the vitamin D status of children in northern China and the association between vitamin D and glucose metabolism. DESIGN: Cross-sectional study was conducted among child participants and retrospective study designs were conducted among adult participants. SETTING AND PARTICIPANTS: Both studies were recruited from Harbin, 326 children were included in children’s study, 8469 adults were included in adult study. PRIMARY AND SECONDARY OUTCOME MEASURES: Physical examination, lifestyle and dietary habit data were recorded in all the participants. Serum insulin, glucose, 25(OH)D(3) concentrations in children and serum glucose and lipids levels in adults were measured. Rickets history was also investigated in adults, which was used to define vitamin D deficiency in childhood. The associations were tested by linear regression and binary logistic regression. RESULT: In the children’s study, only 10.7% of participants were vitamin D sufficient (≥30 ng/mL). Inverse correlations between serum 25(OH)D(3) concentration and fasting insulin and homeostasis model assessment - insulin resistance (HOMA-IR) were found, and children with lower serum 25(OH)D(3) concentrations were likely to have insulin resistance (IR) (OR: 0.955, 95% CI: 0.917 to 0.995, p value: 0.027). In an adult study, rickets in childhood increased the risk of type 2 diabetes in male participants (OR=1.414, 95% CI=1.013 to 1.972; p value=0.042), but this result was not observed in female participants. CONCLUSION: Our findings suggest that vitamin D deficiency is widespread in northern China. Vitamin D deficiency in childhood was associated with IR and increased the risk of type 2 diabetes in male adults.
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spelling pubmed-97103382022-12-01 Vitamin D status in children and its association with glucose metabolism in northern China: a combination of a cross-sectional and retrospective study Liu, Junyi Fu, Liqun Jin, Shanshan Jia, Yubing Zhang, Jingyi Sun, Changhao Na, Lixin BMJ Open Nutrition and Metabolism OBJECTIVES: This study aimed to explore the vitamin D status of children in northern China and the association between vitamin D and glucose metabolism. DESIGN: Cross-sectional study was conducted among child participants and retrospective study designs were conducted among adult participants. SETTING AND PARTICIPANTS: Both studies were recruited from Harbin, 326 children were included in children’s study, 8469 adults were included in adult study. PRIMARY AND SECONDARY OUTCOME MEASURES: Physical examination, lifestyle and dietary habit data were recorded in all the participants. Serum insulin, glucose, 25(OH)D(3) concentrations in children and serum glucose and lipids levels in adults were measured. Rickets history was also investigated in adults, which was used to define vitamin D deficiency in childhood. The associations were tested by linear regression and binary logistic regression. RESULT: In the children’s study, only 10.7% of participants were vitamin D sufficient (≥30 ng/mL). Inverse correlations between serum 25(OH)D(3) concentration and fasting insulin and homeostasis model assessment - insulin resistance (HOMA-IR) were found, and children with lower serum 25(OH)D(3) concentrations were likely to have insulin resistance (IR) (OR: 0.955, 95% CI: 0.917 to 0.995, p value: 0.027). In an adult study, rickets in childhood increased the risk of type 2 diabetes in male participants (OR=1.414, 95% CI=1.013 to 1.972; p value=0.042), but this result was not observed in female participants. CONCLUSION: Our findings suggest that vitamin D deficiency is widespread in northern China. Vitamin D deficiency in childhood was associated with IR and increased the risk of type 2 diabetes in male adults. BMJ Publishing Group 2022-11-29 /pmc/articles/PMC9710338/ /pubmed/36446458 http://dx.doi.org/10.1136/bmjopen-2022-061146 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Nutrition and Metabolism
Liu, Junyi
Fu, Liqun
Jin, Shanshan
Jia, Yubing
Zhang, Jingyi
Sun, Changhao
Na, Lixin
Vitamin D status in children and its association with glucose metabolism in northern China: a combination of a cross-sectional and retrospective study
title Vitamin D status in children and its association with glucose metabolism in northern China: a combination of a cross-sectional and retrospective study
title_full Vitamin D status in children and its association with glucose metabolism in northern China: a combination of a cross-sectional and retrospective study
title_fullStr Vitamin D status in children and its association with glucose metabolism in northern China: a combination of a cross-sectional and retrospective study
title_full_unstemmed Vitamin D status in children and its association with glucose metabolism in northern China: a combination of a cross-sectional and retrospective study
title_short Vitamin D status in children and its association with glucose metabolism in northern China: a combination of a cross-sectional and retrospective study
title_sort vitamin d status in children and its association with glucose metabolism in northern china: a combination of a cross-sectional and retrospective study
topic Nutrition and Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710338/
https://www.ncbi.nlm.nih.gov/pubmed/36446458
http://dx.doi.org/10.1136/bmjopen-2022-061146
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