Severe Generalized Pustular Psoriasis Successfully Treated with Ixekizumab: A Case Report

Generalized pustular psoriasis (GPP) is a severe and potentially life-threatening type of psoriasis. We present the case of a patient with severe GPP, at first unsuccessfully treated with cyclosporine. We chose to treat the patient with ixekizumab, an anti-IL-17 antibody known for its rapid action i...

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Detalles Bibliográficos
Autores principales: Burlando, Martina, Salvi, Ilaria, Paravisi, Andrea, Cozzani, Emanuele, Parodi, Aurora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710421/
https://www.ncbi.nlm.nih.gov/pubmed/36466750
http://dx.doi.org/10.1159/000526037
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author Burlando, Martina
Salvi, Ilaria
Paravisi, Andrea
Cozzani, Emanuele
Parodi, Aurora
author_facet Burlando, Martina
Salvi, Ilaria
Paravisi, Andrea
Cozzani, Emanuele
Parodi, Aurora
author_sort Burlando, Martina
collection PubMed
description Generalized pustular psoriasis (GPP) is a severe and potentially life-threatening type of psoriasis. We present the case of a patient with severe GPP, at first unsuccessfully treated with cyclosporine. We chose to treat the patient with ixekizumab, an anti-IL-17 antibody known for its rapid action in psoriasis vulgaris, that has also been reported as effective in GPP. The patient improved rapidly, with resolution of the active lesions after the first administration. The treatment has been continued for 2 years, with no adverse events and sustained disease control. Ixekizumab could be considered a safe and effective option in patients with GPP.
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spelling pubmed-97104212022-12-01 Severe Generalized Pustular Psoriasis Successfully Treated with Ixekizumab: A Case Report Burlando, Martina Salvi, Ilaria Paravisi, Andrea Cozzani, Emanuele Parodi, Aurora Case Rep Dermatol Single Case Generalized pustular psoriasis (GPP) is a severe and potentially life-threatening type of psoriasis. We present the case of a patient with severe GPP, at first unsuccessfully treated with cyclosporine. We chose to treat the patient with ixekizumab, an anti-IL-17 antibody known for its rapid action in psoriasis vulgaris, that has also been reported as effective in GPP. The patient improved rapidly, with resolution of the active lesions after the first administration. The treatment has been continued for 2 years, with no adverse events and sustained disease control. Ixekizumab could be considered a safe and effective option in patients with GPP. S. Karger AG 2022-11-04 /pmc/articles/PMC9710421/ /pubmed/36466750 http://dx.doi.org/10.1159/000526037 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Burlando, Martina
Salvi, Ilaria
Paravisi, Andrea
Cozzani, Emanuele
Parodi, Aurora
Severe Generalized Pustular Psoriasis Successfully Treated with Ixekizumab: A Case Report
title Severe Generalized Pustular Psoriasis Successfully Treated with Ixekizumab: A Case Report
title_full Severe Generalized Pustular Psoriasis Successfully Treated with Ixekizumab: A Case Report
title_fullStr Severe Generalized Pustular Psoriasis Successfully Treated with Ixekizumab: A Case Report
title_full_unstemmed Severe Generalized Pustular Psoriasis Successfully Treated with Ixekizumab: A Case Report
title_short Severe Generalized Pustular Psoriasis Successfully Treated with Ixekizumab: A Case Report
title_sort severe generalized pustular psoriasis successfully treated with ixekizumab: a case report
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710421/
https://www.ncbi.nlm.nih.gov/pubmed/36466750
http://dx.doi.org/10.1159/000526037
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