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Effect of electroacupuncture on the repair of stress ulcer injury in neurocritical patients: A randomized clinical trial
BACKGROUND: Stress ulcer (SU) is one of the main causes of prolonged hospital stay, poor prognosis, and increased mortality in critically ill patients. This study aimed to investigate the effect of electroacupuncture (EA) on SU in patients with severe neurological diseases and explore its possible m...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710539/ https://www.ncbi.nlm.nih.gov/pubmed/36465896 http://dx.doi.org/10.3389/fmed.2022.1001584 |
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author | Li, He Li, Li-li Wang, Jian Wang, Yong-qiang Wang, Lan Yuan, Lan Chen, Wen-ting Song, Jian-gang |
author_facet | Li, He Li, Li-li Wang, Jian Wang, Yong-qiang Wang, Lan Yuan, Lan Chen, Wen-ting Song, Jian-gang |
author_sort | Li, He |
collection | PubMed |
description | BACKGROUND: Stress ulcer (SU) is one of the main causes of prolonged hospital stay, poor prognosis, and increased mortality in critically ill patients. This study aimed to investigate the effect of electroacupuncture (EA) on SU in patients with severe neurological diseases and explore its possible mechanisms. METHODS: Taking patients with SU in adult neurocritical care as the research object, they were randomly divided into the EA group and the control group. Through the perioperative EA intervention, the following indicators were documented: main observation indicator (the effective rate of SU treatment), secondary observation indicators (gastric juice pH, gastric juice occult blood test, and stool occult blood test), related mechanisms [repair factors trefoil factor family 2 (TFF2), vascular endothelial growth factor (VEGF), and heat shock protein 70 (HSP70)], complications during hospitalization, and intensive care unit (ICU) stay time. RESULTS: Compared with the control treatment, EA increased the effective rate of SU treatment (85.4% for the EA group, 57.5% for the control group, risk difference: 27.9% (95% CI: 8.3%–45.1%); P < 0.01). EA increased the success rate of gastric juice pH treatment on days 1, 2, and 3 (P < 0.01 for day 1, P < 0.05 for days 2 and 3). EA lowered the positive rate of gastric occult blood test on days 1 and 3 (all P-values < 0.05) and the positive rate of fecal occult blood test on day 3 (P < 0.05). EA also reduced the ICU stay time (P < 0.01) and total hospitalization time (P < 0.05). Compared with day 0, all serum repair factors (VEGF, HSP70, and TFF2) of both groups significantly increased on days 1, 3, and 5 (all P-values < 0.01). Compared with the control group, VEGF in the EA group was increased on days 3 and 5 (all P-values < 0.01); HSP70 was increased on days 1, 3, and 5 (P < 0.05 for day 1, P < 0.01 for days 3 and 5); and TFF2 was increased on days 1, 3, and 5 (all P-values < 0.01). CONCLUSION: Electroacupuncture promoted the repair of SU damage in severe neurological disease, and its effect was related to enhancing the expression of gastric mucosal repair factors. CLINICAL TRIAL REGISTRATION: [https://www.chictr.org.cn/showprojen.aspx?proj=127012], identifier [ChiCTR2100046701]. |
format | Online Article Text |
id | pubmed-9710539 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97105392022-12-01 Effect of electroacupuncture on the repair of stress ulcer injury in neurocritical patients: A randomized clinical trial Li, He Li, Li-li Wang, Jian Wang, Yong-qiang Wang, Lan Yuan, Lan Chen, Wen-ting Song, Jian-gang Front Med (Lausanne) Medicine BACKGROUND: Stress ulcer (SU) is one of the main causes of prolonged hospital stay, poor prognosis, and increased mortality in critically ill patients. This study aimed to investigate the effect of electroacupuncture (EA) on SU in patients with severe neurological diseases and explore its possible mechanisms. METHODS: Taking patients with SU in adult neurocritical care as the research object, they were randomly divided into the EA group and the control group. Through the perioperative EA intervention, the following indicators were documented: main observation indicator (the effective rate of SU treatment), secondary observation indicators (gastric juice pH, gastric juice occult blood test, and stool occult blood test), related mechanisms [repair factors trefoil factor family 2 (TFF2), vascular endothelial growth factor (VEGF), and heat shock protein 70 (HSP70)], complications during hospitalization, and intensive care unit (ICU) stay time. RESULTS: Compared with the control treatment, EA increased the effective rate of SU treatment (85.4% for the EA group, 57.5% for the control group, risk difference: 27.9% (95% CI: 8.3%–45.1%); P < 0.01). EA increased the success rate of gastric juice pH treatment on days 1, 2, and 3 (P < 0.01 for day 1, P < 0.05 for days 2 and 3). EA lowered the positive rate of gastric occult blood test on days 1 and 3 (all P-values < 0.05) and the positive rate of fecal occult blood test on day 3 (P < 0.05). EA also reduced the ICU stay time (P < 0.01) and total hospitalization time (P < 0.05). Compared with day 0, all serum repair factors (VEGF, HSP70, and TFF2) of both groups significantly increased on days 1, 3, and 5 (all P-values < 0.01). Compared with the control group, VEGF in the EA group was increased on days 3 and 5 (all P-values < 0.01); HSP70 was increased on days 1, 3, and 5 (P < 0.05 for day 1, P < 0.01 for days 3 and 5); and TFF2 was increased on days 1, 3, and 5 (all P-values < 0.01). CONCLUSION: Electroacupuncture promoted the repair of SU damage in severe neurological disease, and its effect was related to enhancing the expression of gastric mucosal repair factors. CLINICAL TRIAL REGISTRATION: [https://www.chictr.org.cn/showprojen.aspx?proj=127012], identifier [ChiCTR2100046701]. Frontiers Media S.A. 2022-11-16 /pmc/articles/PMC9710539/ /pubmed/36465896 http://dx.doi.org/10.3389/fmed.2022.1001584 Text en Copyright © 2022 Li, Li, Wang, Wang, Wang, Yuan, Chen and Song. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Li, He Li, Li-li Wang, Jian Wang, Yong-qiang Wang, Lan Yuan, Lan Chen, Wen-ting Song, Jian-gang Effect of electroacupuncture on the repair of stress ulcer injury in neurocritical patients: A randomized clinical trial |
title | Effect of electroacupuncture on the repair of stress ulcer injury in neurocritical patients: A randomized clinical trial |
title_full | Effect of electroacupuncture on the repair of stress ulcer injury in neurocritical patients: A randomized clinical trial |
title_fullStr | Effect of electroacupuncture on the repair of stress ulcer injury in neurocritical patients: A randomized clinical trial |
title_full_unstemmed | Effect of electroacupuncture on the repair of stress ulcer injury in neurocritical patients: A randomized clinical trial |
title_short | Effect of electroacupuncture on the repair of stress ulcer injury in neurocritical patients: A randomized clinical trial |
title_sort | effect of electroacupuncture on the repair of stress ulcer injury in neurocritical patients: a randomized clinical trial |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710539/ https://www.ncbi.nlm.nih.gov/pubmed/36465896 http://dx.doi.org/10.3389/fmed.2022.1001584 |
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