PERCC1, a new member of the Yap/TAZ/FAM181 transcriptional co-regulator family

MOTIVATION: Disrupted PERCC1 gene expression causes an intractable congenital diarrhoea in infants. However, this gene’s molecular mechanism is unknown and no homologous proteins have been reported. RESULTS: Our detailed evolutionary analysis of PERCC1 sequence reveals it to be a previously unappreciated member of the YAP/TAZ/FAM181 family of homologous transcriptional regulators. Like YAP and TAZ, PERCC1 likely interacts with DNA via binding to TEA/ATTS domain transcription factors (TEADs) using its conserved interface-2 and -3 sequences. We compare the expression patterns of PERCC1 with those of YAP, TAZ, TEADs. Our report provides the identification and first in-depth bioinformatic analysis of a YAP/TAZ homologue, and a likely new regulator of the YAP/TAZ-TEAD transcriptional complex. AVAILABILITY AND IMPLEMENTATION: The data underlying this article are available in UniProt Database. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics Advances online.