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PhenoComb: a discovery tool to assess complex phenotypes in high-dimensional single-cell datasets

MOTIVATION: High-dimensional cytometry assays can simultaneously measure dozens of markers, enabling the investigation of complex phenotypes. However, as manual gating relies on previous biological knowledge, few marker combinations are often assessed. This results in complex phenotypes with the pot...

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Detalles Bibliográficos
Autores principales: Burke, Paulo E P, Strange, Ann, Monk, Emily, Thompson, Brian, Amato, Carol M, Woods, David M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710698/
https://www.ncbi.nlm.nih.gov/pubmed/36699375
http://dx.doi.org/10.1093/bioadv/vbac052