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Portuguese version of the CDR plus NACC FTLD: Validation studies
INTRODUCTION: The CDR Dementia Staging Instrument PLUS National Alzheimer’s Coordinating Center (CDR plus NACC FTLD) was developed by adding to the standard CDR two extra domains focused on the main features of frontotemporal lobar degeneration (FTLD): language and behavior/personality. We intended...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710719/ https://www.ncbi.nlm.nih.gov/pubmed/36466956 http://dx.doi.org/10.1002/dad2.12355 |
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author | Lima, Marisa Tábuas‐Pereira, Miguel Durães, João Faustino, Pedro Simões, Mário R. Kukull, Walter Knopman, David S. Santana, Isabel |
author_facet | Lima, Marisa Tábuas‐Pereira, Miguel Durães, João Faustino, Pedro Simões, Mário R. Kukull, Walter Knopman, David S. Santana, Isabel |
author_sort | Lima, Marisa |
collection | PubMed |
description | INTRODUCTION: The CDR Dementia Staging Instrument PLUS National Alzheimer’s Coordinating Center (CDR plus NACC FTLD) was developed by adding to the standard CDR two extra domains focused on the main features of frontotemporal lobar degeneration (FTLD): language and behavior/personality. We intended to perform the validation studies for the European‐Portuguese population. METHODS: A total of 105 participants matched for age, education, and disease staging (35 bvFTD, 35 AD, and 35 controls) were included. A translated‐version of the CDR and the two added domains was administered by a neuropsychologist who was blinded to the diagnosis. RESULTS: The bvFTD group had higher baseline CDR plus NACC FTLD scores compared to the AD and controls. Only the sum‐of‐boxes (SB) score, the behavior/personality, and language domains were able to distinguish between clinical groups. Logistic regression analyses showed that adding the behavior/personality domain with or without language significantly enhanced the discriminating ability. DISCUSSION: Results show that the CDR plus NACC FTLD is a reliable tool in the diagnostic process of bvFTD patients and has an added value in distinguishing them from patients with AD. |
format | Online Article Text |
id | pubmed-9710719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97107192022-12-02 Portuguese version of the CDR plus NACC FTLD: Validation studies Lima, Marisa Tábuas‐Pereira, Miguel Durães, João Faustino, Pedro Simões, Mário R. Kukull, Walter Knopman, David S. Santana, Isabel Alzheimers Dement (Amst) Research Articles INTRODUCTION: The CDR Dementia Staging Instrument PLUS National Alzheimer’s Coordinating Center (CDR plus NACC FTLD) was developed by adding to the standard CDR two extra domains focused on the main features of frontotemporal lobar degeneration (FTLD): language and behavior/personality. We intended to perform the validation studies for the European‐Portuguese population. METHODS: A total of 105 participants matched for age, education, and disease staging (35 bvFTD, 35 AD, and 35 controls) were included. A translated‐version of the CDR and the two added domains was administered by a neuropsychologist who was blinded to the diagnosis. RESULTS: The bvFTD group had higher baseline CDR plus NACC FTLD scores compared to the AD and controls. Only the sum‐of‐boxes (SB) score, the behavior/personality, and language domains were able to distinguish between clinical groups. Logistic regression analyses showed that adding the behavior/personality domain with or without language significantly enhanced the discriminating ability. DISCUSSION: Results show that the CDR plus NACC FTLD is a reliable tool in the diagnostic process of bvFTD patients and has an added value in distinguishing them from patients with AD. John Wiley and Sons Inc. 2022-11-30 /pmc/articles/PMC9710719/ /pubmed/36466956 http://dx.doi.org/10.1002/dad2.12355 Text en © 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Lima, Marisa Tábuas‐Pereira, Miguel Durães, João Faustino, Pedro Simões, Mário R. Kukull, Walter Knopman, David S. Santana, Isabel Portuguese version of the CDR plus NACC FTLD: Validation studies |
title | Portuguese version of the CDR plus NACC FTLD: Validation studies |
title_full | Portuguese version of the CDR plus NACC FTLD: Validation studies |
title_fullStr | Portuguese version of the CDR plus NACC FTLD: Validation studies |
title_full_unstemmed | Portuguese version of the CDR plus NACC FTLD: Validation studies |
title_short | Portuguese version of the CDR plus NACC FTLD: Validation studies |
title_sort | portuguese version of the cdr plus nacc ftld: validation studies |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710719/ https://www.ncbi.nlm.nih.gov/pubmed/36466956 http://dx.doi.org/10.1002/dad2.12355 |
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