SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression

Epidemiological data demonstrate that Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) Alpha and Delta are more transmissible, infectious, and pathogenic than previous variants. Phenotypic properties of VOC remain understudied. Here, we provide an extensive fun...

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Autores principales: Niemeyer, Daniela, Stenzel, Saskia, Veith, Talitha, Schroeder, Simon, Friedmann, Kirstin, Weege, Friderike, Trimpert, Jakob, Heinze, Julian, Richter, Anja, Jansen, Jenny, Emanuel, Jackson, Kazmierski, Julia, Pott, Fabian, Jeworowski, Lara M., Olmer, Ruth, Jaboreck, Mark-Christian, Tenner, Beate, Papies, Jan, Walper, Felix, Schmidt, Marie L., Heinemann, Nicolas, Möncke-Buchner, Elisabeth, Baumgardt, Morris, Hoffmann, Karen, Widera, Marek, Thao, Tran Thi Nhu, Balázs, Anita, Schulze, Jessica, Mache, Christin, Jones, Terry C., Morkel, Markus, Ciesek, Sandra, Hanitsch, Leif G., Mall, Marcus A., Hocke, Andreas C., Thiel, Volker, Osterrieder, Klaus, Wolff, Thorsten, Martin, Ulrich, Corman, Victor M., Müller, Marcel A., Goffinet, Christine, Drosten, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710838/
https://www.ncbi.nlm.nih.gov/pubmed/36383605
http://dx.doi.org/10.1371/journal.pbio.3001871

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