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spKAS-seq reveals R-loop dynamics using low-input materials by detecting single-stranded DNA with strand specificity
R-loops affect transcription and genome stability. Dysregulation of R-loops is related to human diseases. Genome-wide R-loop mapping typically uses the S9.6 antibody or inactive ribonuclease H, both requiring a large number of cells with varying results observed depending on the approach applied. He...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710868/ https://www.ncbi.nlm.nih.gov/pubmed/36449625 http://dx.doi.org/10.1126/sciadv.abq2166 |