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Stimulation of RAS-dependent ROS signaling extends longevity by modulating a developmental program of global gene expression

We show that elevation of mitochondrial superoxide generation increases Caenorhabditis elegans life span by enhancing a RAS-dependent ROS (reactive oxygen species) signaling pathway (RDRS) that controls the expression of half of the genome as well as animal composition and physiology. RDRS stimulati...

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Detalles Bibliográficos
Autores principales:	Branicky, Robyn, Wang, Ying, Khaki, Arman, Liu, Ju-Ling, Kramer-Drauberg, Maximilian, Hekimi, Siegfried
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710873/ https://www.ncbi.nlm.nih.gov/pubmed/36449615 http://dx.doi.org/10.1126/sciadv.adc9851

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