Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration

Autophagy is essential for neuronal development and its deregulation contributes to neurodegenerative diseases. NDR1 and NDR2 are highly conserved kinases, implicated in neuronal development, mitochondrial health and autophagy, but how they affect mammalian brain development in vivo is not known. Us...

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Detalles Bibliográficos
Autores principales: Roşianu, Flavia, Mihaylov, Simeon R, Eder, Noreen, Martiniuc, Antonie, Claxton, Suzanne, Flynn, Helen R, Jalal, Shamsinar, Domart, Marie-Charlotte, Collinson, Lucy, Skehel, Mark, Snijders, Ambrosius P, Krause, Matthias, Tooze, Sharon A, Ultanir, Sila K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9711861/
https://www.ncbi.nlm.nih.gov/pubmed/36446521
http://dx.doi.org/10.26508/lsa.202201712

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