Bring on the brequinar: an approach to enforce the differentiation of myeloid-derived suppressor cells

Myeloid-derived suppressor cells (MDSCs) hinder antitumor immunity in multiple cancer types. While brequinar (BRQ), an inhibitor of dihydroorotate dehydrogenase, shows cytotoxicity in hematological malignancy, it has not yet been adapted to attenuate MDSCs by augmenting bone marrow progenitors in br...

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Detalles Bibliográficos
Autores principales: Horvat, Natalie K., Lesinski, Gregory B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9711868/
https://www.ncbi.nlm.nih.gov/pubmed/36453548
http://dx.doi.org/10.1172/JCI165506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9711868/
https://www.ncbi.nlm.nih.gov/pubmed/36453548
http://dx.doi.org/10.1172/JCI165506

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