Cyclin G1 induces maladaptive proximal tubule cell dedifferentiation and renal fibrosis through CDK5 activation

Acute kidney injury (AKI) occurs in approximately 13% of hospitalized patients and predisposes patients to chronic kidney disease (CKD) through the AKI-to-CKD transition. Studies from our laboratory and others have demonstrated that maladaptive repair of proximal tubule cells (PTCs), including induc...

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Detalles Bibliográficos
Autores principales: Taguchi, Kensei, Elias, Bertha C., Sugahara, Sho, Sant, Snehal, Freedman, Benjamin S., Waikar, Sushrut S., Pozzi, Ambra, Zent, Roy, Harris, Raymond C., Parikh, Samir M., Brooks, Craig R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9711881/
https://www.ncbi.nlm.nih.gov/pubmed/36453545
http://dx.doi.org/10.1172/JCI158096

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