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In vivo PDX CRISPR/Cas9 screens reveal mutual therapeutic targets to overcome heterogeneous acquired chemo-resistance

Resistance towards cancer treatment represents a major clinical obstacle, preventing cure of cancer patients. To gain mechanistic insights, we developed a model for acquired resistance to chemotherapy by treating mice carrying patient derived xenografts (PDX) of acute lymphoblastic leukemia with wid...

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Detalles Bibliográficos
Autores principales:	Wirth, Anna-Katharina, Wange, Lucas, Vosberg, Sebastian, Henrich, Kai-Oliver, Rausch, Christian, Özdemir, Erbey, Zeller, Christina M., Richter, Daniel, Feuchtinger, Tobias, Kaller, Markus, Hermeking, Heiko, Greif, Philipp A., Senft, Daniela, Jurinovic, Vindi, Bahrami, Ehsan, Jayavelu, Ashok Kumar, Westermann, Frank, Mann, Matthias, Enard, Wolfgang, Herold, Tobias, Jeremias, Irmela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712105/ https://www.ncbi.nlm.nih.gov/pubmed/36333584 http://dx.doi.org/10.1038/s41375-022-01726-7

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